单次大剂量丙种球蛋白治疗新生儿ABO溶血病的效果

Effect of single large dose of γ-globulin in the treatment of neonatal ABO hemolytic disease

目的探讨单次大剂量丙种球蛋白治疗新生儿ABO溶血病的效果。方法 52例ABO溶血病新生儿作为研究对象,按照随机数字表分组法分为观察组与对照组,各26例。对照组患儿给予多次小剂量丙种球蛋白治疗,观察组给予单次大剂量丙种球蛋白治疗。比较两组患儿治疗前与治疗1、2、3 d后胆红素水平;治疗前与治疗30 d后红细胞计数;黄疸达高峰时间、黄疸消退时间及黄疸高峰期胆红素水平。结果治疗1 d后,观察组患儿的胆红素水平为(213.4±76.5)μmol/L,低于对照组的(298.3±81.6)μmol/L,差异具有统计学意义(P<0.05);治疗2 d后,观察组患儿的胆红素水平为(206.8±67.2)μmol/L,低于对照组的(278.2±72.2)μmol/L,差异具有统计学意义(P<0.05);治疗3 d后,观察组患儿的胆红素水平为(191.8±61.5)μmol/L,低于对照组的(258.3±54.4)μmol/L,差异具有统计学意义(P<0.05)。治疗30 d后,观察组患儿的红细胞计数为(3.84±0.53)×10^12/L,高于对照组的(3.39±0.51)×10^12/L,差异具有统计学意义(P<0.05)。两组患儿的黄疸达高峰时间、高峰期胆红素水平比较差异均无统计学意义(P>0.05);两组患儿的黄疸消退时间比较差异具有统计学意义(P<0.05)。结论给予ABO溶血病患儿单次大剂量丙种球蛋白治疗,效果显著,值得临床推广与应用。

Objective To discuss the effect of single dose ofγ-globulin in the treatment of neonatal ABO hemolytic disease.Methods A total of 52 cases of neonatal ABO hemolytic disease as study subjects were divided into observation group and control group,with 26 cases in each group.The control group was treated by multiple lowdose ofγ-globulin,and the observation group was treated by single large dose ofγ-globulin.Comparison was made on bilirubin level before treatment and after 1,2 and 3 d of treatment;red blood cell count before treatment and after 30 d of treatment;jaundice arriving peak time,jaundice regression time and bilirubin level during peak jaundice between the two groups.Results After 1 d of treatment,the bilirubin level was(213.4±76.5)μmol/L in the observation group,which was lower than(298.3±81.6)μmol/L in the control group,and the difference was statistically significant(P<0.05).After 2 d of treatment,the bilirubin level was(206.8±67.2)μmol/L in the observation group,which was lower than(278.2±72.2)μmol/L in the control group,and the difference was statistically significant(P<0.05).After 3 d of treatment,the bilirubin level was(191.8±61.5)μmol/L in the observation group,which was lower than(258.3±54.4)μmol/L in the control group,and the difference was statistically significant(P<0.05).After 30 d of treatment,the red blood cell count was(3.84±0.53)×10^12/L in the observation group,which was higher than(3.39±0.51)×10^12/L in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in jaundice arriving peak time and bilirubin level during peak jaundice between the two groups(P>0.05).There was statistically significant difference in jaundice regression time between the two groups(P<0.05).Conclusion Single large dose ofγ-globulin shows remarkable effect in the treatment of ABO hemolytic disease children,and it is worthy of clinical promotion and application.