IDEAL-IQ序列脂肪分数值评估早期干燥综合征腮腺脂肪浸润的价值

The research value of quantitative study of parotid gland fat infiltration in early Sjogren’s syndrome patients by using 3.0 T MR IDEAL-IQ sequence

目的采用3.0 T MR IDEAL-IQ序列定量测量早期干燥综合征患者与健康志愿者腮腺的脂肪分数(FF)值,评估腮腺的脂肪浸润情况,以期为临床提供有价值的诊断新依据。材料与方法选取2019年1月至2019年7月于青岛市市立医院就诊的31例早期干燥综合征女性患者和30例健康女性志愿者进行腮腺MRI常规序列扫描及IDEAL-IQ序列横轴位扫描。利用GE ADW 4.6工作站处理软件测定腮腺FF值,分别对早期干燥综合征患者及健康志愿者的双侧腮腺FF值测量后进行统计学分析。结果两组间年龄、BMI构成的差异无统计学意义(P>0.05)。早期干燥综合征患者及健康志愿者腮腺腺体FF值均无侧别差异(P>0.05),早期干燥综合征患者腮腺平均FF值明显高于正常组(48.84±11.26与32.15±6.58,P<0.01)。以平均FF值37.62作为诊断阈值,诊断早期干燥综合征的价值最优(AUC=0.92,敏感度0.88,特异度0.81)。结论腮腺IDEAL-IQ序列及FF值在诊断早期干燥综合征中具有一定的作用,可为诊断早期干燥综合征提供有价值的影像学信息。

Objective:To quantitatively measure the fat fraction(FF)of parotid gland in patients with early Sjogren’s syndrome and healthy volunteers by using 3.0 T MR IDEAL-IQ sequence,and to evaluate the infiltration of parotid gland fat,so as to provide a new diagnostic basis for the clinic.Materials and Methods:From January 2019 to July 2019,31 female patients with early Sjogren’s syndrome and 30 healthy female volunteers admitted to Qingdao municipal hospital were enrolled in the routine parotid MRI sequence scanning and the IDEAL-IQ sequence axial scanning.The GE ADW 4.6 workstation processing software was used to quantitatively measure the FF value of the parotid gland,and statistical analysis was performed on the FF values of the bilateral parotid glands in the early Sjogren’s syndrome patients and healthy volunteers.Results:There was no significant difference in age and BMI between the two groups(P>0.05).There were no differences on FF values in the left and right parotid gland in patients with early Sjogren’s syndrome andhealthy volunteers(P>0.05).The mean FF value of parotid gland in patients with early Sjogren’s syndrome was significantly higher than that in the normal group(48.84±11.26 vs 32.15±6.58,P<0.01).The mean FF 37.62 was taken as the optimal value for early Sjogren’s syndrome diagnosis(AUC=0.92,sensitivity 0.88,specificity 0.81).Conclusions:The IDEAL-IQ sequence and FF value of parotid gland play a certain role in the diagnosis of early Sjogren’s syndrome,which can provide valuable information for the diagnosis of early Sjogren’s syndrome.