采用脑电图对接受卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫进行疗效评估

Electroencephalogram(EEG) was Used to Evaluate the Efficacy of Carbamazepine Topiramate and Sodium Valproate in the Treatment of Epileptic Secondary to Meningitis

目的探讨采用脑电图对接受卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫进行疗效评估。方法将120例脑炎继发癫痫患者,根据临床治疗分为卡马西平组、托吡酯组和丙戊酸钠组,各40例,三组均采用相应药物治疗,疗程为1年,比较两组治疗效果及安全性。结果临床疗效:托吡酯组(87.50%)>丙戊酸钠组(75.0%)>卡马西平组(70.0%),三组差异显著(P<0.05);不良反应发生率:托吡酯组(5.0%<丙戊酸钠组27.50%)<卡马西平组(37.5%),三组差异显著(P<0.05)。结论三者治疗脑炎继发癫痫均有疗效,且托吡酯疗效与安全性最高,卡马西平不良反应最多。

Objective To evaluate the efficacy of electroencephalogram(EEG)in the treatment of secondary epilepsy of encephalitis with carbamazepine,tropide and valproate.Methods 20 patients with epilepsy secondary to encephalitis were divided into carbamazepine group,topiramate group and sodium valproate group according to the clinical treatment,40 cases in each group.All the three groups were treated with corresponding drugs for one year.The therapeutic effect and safety of the two groups were compared.Results Clinical efficacy:Topiramate group(87.50%),sodium valproate group(75.0%)and carbamazepine group(70.0%)showed significant difference among the three groups(P<0.05).Incidence of adverse reactions:Topiramate group(5.0%<sodium valproate group27.50%)and carbamazepine group(37.5%)had significant difference among the three groups(P<0.05).Conclusion All the three treatments are effective in treating epilepsy secondary to encephalitis,and topiramate has the highest efficacy and safety,and carbamazepine has the most adverse reactions.