瑞舒伐他汀钙片对急性脑梗死合并糖尿病的疗效观察

Observation on efficacy of rosuvastatin calcium tablet on acute cerebral infarction with diabetes mellitus

目的 探讨急性脑梗死合并糖尿病患者应用瑞舒伐他汀钙片治疗的临床效果。方法 102例急性脑梗死合并糖尿病患者为研究对象,根据随机数字表法分为观察组和对照组,各51例。两组患者入院后均行常规治疗,在此基础上对照组采用阿司匹林肠溶片治疗,观察组在对照组基础上采用瑞舒伐他汀钙片治疗。比较两组临床疗效、治疗前后血脂水平、神经功能和日常生活能力(ADL)评分。结果 观察组总有效率92.16%高于对照组的72.55%,差异具有统计学意义(P<0.05)。治疗后,观察组的低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)水平分别为(2.6±0.1)、(1.4±0.2)、(4.0±0.3)mmol/L,均低于对照组的(3.2±0.5)、(1.7±0.1)、(4.5±0.2)mmol/L,高密度脂蛋白胆固醇(HDL-C)水平(1.19±0.11)mmol/L高于对照组的(1.10±0.12)mmol/L,差异均有统计学意义(P<0.05)。治疗后,观察组的ADL评分(68.93±10.24)分高于对照组的(51.13±17.35)分,美国国立卫生研究院卒中量表(NIHSS)评分(3.27±1.33)分低于对照组的(5.46±1.25)分,差异均有统计学意义(P<0.05)。结论 瑞舒他汀钙片治疗急性脑梗死合并糖尿病效果显著,不仅可以改善血脂水平,还能减轻神经功能损伤,改善患者预后,值得临床推广。

Objective To discuss the clinical effect of rosuvastatin calcium tablet on patients with acute cerebral infarction and diabetes mellitus.Methods A total of 102 patients with acute cerebral infarction and diabetes mellitus as study subjects were divided into observation group and control group,with 51 cases in each group.Both groups received conventional therapy,and on this basis,the control group received aspirin enteric-coated tablets for treatment.The observation group received rosuvastatin calcium tablet for treatment.The clinical efficacy,blood lipid level,nerve function and activities of daily life(ADL)score before and after treatment was compared between the two groups.Results The total effective rate 92.16% in the observation group was higher than 72.55% in the control group,and the difference was statistically significant(P<0.05).After treatment,the low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)was(2.6±0.1),(1.4±0.2)and(4.0±0.3)mmol/L respectively in the observation group,which was lower than(3.2±0.5),(1.7±0.1)and(4.5±0.2)mmol/L in the control group,and high density lipoprotein cholesterol(HDL-C)(1.19±0.11)mmol/L was lower higher than(1.10±0.12)mmol/L in the control group.Their difference was statistically significant(P<0.05).After treatment,the ADL score(68.93±10.24)points in the observation group was higher than(51.13±17.35)points in the control group,and National Institutes of Health stroke scale(NIHSS)score(3.27±1.33)points was lower than(5.46±1.25)points in the control group.Their difference was statistically significant(P<0.05).Conclusion Rosuvastatin calcium tablet shows remarkable effect in the treatment of diabetes mellitus with acute cerebral infarction,and it can not only improve blood lipid level,but also reduce injury of nerve function and improve the prognosis of patients.It is worthy of clinical promotion.