奥氮平与利培酮治疗冰毒所致精神障碍的疗效

Efficacy of olanzapine and risperidone in the treatment of mental disorders caused by methamphetamine

目的 探讨奥氮平与利培酮治疗冰毒所致精神障碍的效果。方法 冰毒所致精神障碍患者100例,采用双盲分组法将其分为观察组与对比组,各50例。对比组患者使用利培酮治疗,观察组患者使用奥氮平治疗,对比分析两组治疗前后阳性和阴性症状量表(PANSS)评分和治疗效果。结果 治疗后,观察组一般精神病理评分(19.52±6.32)分、阴性症状评分(14.42±4.25)分均低于对比组的(25.14±6.54)、(16.98±4.18)分,阳性症状评分(56.28±12.71)分高于对比组的(51.16±11.69)分,差异有统计学意义(P<0.05)。观察组治疗总有效率为94.00%,高于对比组的80.00%,差异有统计学意义(P<0.05)。结论 奥氮平治疗冰毒所致精神障碍效果更佳,具有较好的临床应用价值。

Objective To discuss the therapeutic effect of olanzapine and risperidone in the treatment of mental disorders caused by methamphetamine.Methods A total of 100 cases of mental disorders caused by methamphetamine were divided into observation group and control group by double-blind method,with 50 cases in each group.The control group was treated by risperidone,and the observation group was treated by olanzapine.The positive and negative syndrome scale(PANSS)score before and after treatment and therapeutic effect was compared and analyzed in the two groups.Results After treatment,the general psychopathology score(19.52±6.32)points and negative symptom score(14.42±4.25)points in the observation group was lower than(25.14±6.54)and(16.98±4.18)points in the control group,and positive symptom score(56.28±12.71)points was higher than(51.16±11.69)points in the control group.Their difference was statistically significant(P<0.05).The total effective rate of treatment was 94.00% in the observation group,which was higher than 80.00% in the control group,and the difference was statistically significant(P<0.05).Conclusion Olanzapine shows better therapeutic effect for mental disorders caused by methamphetamine,and it contains good clinical application value.