摘要
目的:研究调q激光治疗户外紫外线(UVB)诱导的黄褐斑豚鼠模型的效果及可能机制。方法:选取UVB诱导的黄褐斑模型豚鼠20只,随机分为实验组(调q激光治疗组)和对照组(氢醌治疗组),每组各10只。实验组予以调q激光治疗,对照组给予氢醌治疗。4个月后观察各组豚鼠皮损变化及皮损组织病理改变。结果:实验组与对照组相比,皮损肉眼观及组织病理免疫组化表现均明显改善。结论:调q激光治疗黄褐斑豚鼠疗效显著,可能与调q激光选择性破坏黑素细胞、减少黑色素生成有关。
Objective:To explore the effect and the possible mechanism of q-switched Laser in the treatment for melasma mouse model induced by UVB.Methods:All 20 mice with chloasma induced by UVB were randomly divided into two groups:treatment group(q-switched laser therapy),the control group(hydroquinone therapy).The changes of skin lesions and pathological changes of skin lesions in each group were observed after 4 months.Results:The skin lesion performances and the histopathological manifestations of skin lesions of mice in treatment group was improved than that of control group B.Conclusion:The curative effect of q-switched Laser in melasma mouse model was significantly,which may be related to the selective destruction of q-switched Laser for melanocyte.
作者
甘小艳
胡婷婷
蒋甜甜
冯浩
GAN Xiaoyan;HU Tingting;JIANG Tiantian;FENG Hao(Yongzhou Central Hospital,Yongzhou 425000,China;Hunan Provincial People's Hospital,Changsha 410005,China)
出处
《临床医药实践》
2020年第1期28-29,60,共3页
Proceeding of Clinical Medicine
基金
永州市科技创新及应用研究项目（项目编号：永财企指[2016]26号）
关键词
黄褐斑
调Q激光
模型鼠
chloasma
q-switched laser
mouse model
