2型糖尿病大血管并发症的影响因素

Influencing factors of macrovascular complications in type 2 diabetes mellitus

我国2型糖尿病的发病率逐年升高,其引起的慢性并发症也非常普遍。其中,大血管并发症是2型糖尿病患者致死的最主要原因,糖尿病大血管并发症与传统的心血管疾病发病机制并不完全相同。研究发现2型糖尿病大血管并发症不仅与年龄、性别、高血压、吸烟、BMI、糖尿病病程、血脂、糖化血红蛋白等传统的心血管疾病的危险因素相关,其他因素如糖尿病微血管并发症、一些特定分子蛋白和个体的基因背景也影响着2型糖尿病大血管并发症的发生。本文对影响2型糖尿病大血管并发症发生的临床因素、分子蛋白和基因背景进行综述。

The incidence of type 2 diabetes in China is increasing annually,and its chronic complications are very common.Macrovascular complications are the main cause of death in patients with type 2 diabetes mellitus.The pathogenesis of diabetic macrovascular complications is different from that of traditional cardiovascular diseases.It has been found that macrovascular complications of type 2 diabetes are not only related to traditional cardiovascular disease risk factors (age,gender,hypertension,smoking,body mass index,diabetes duration,serum lipid,and glycosylated hemoglobin),but also diabetic microvascular complications,some specific molecular proteins and individual genetic background.This article reviews the clinical factors,molecular proteins and genetic background that affect the incidence of macrovascular complications in type 2 diabetes.