2型糖尿病患者眼表改变的研究进展

Ocular surface changes in patients with type 2 diabetes mellitus:research progress

糖尿病可引发视网膜病变、视神经病变、新生血管性青光眼和代谢性白内障等多种眼部并发症,在致盲性眼病中占有重要位置。既往对糖尿病性视网膜病变的相关研究较多,但对糖尿病性眼表改变研究较少。糖尿病导致的眼表改变包括泪腺、睑板腺、结膜、泪膜、角膜等的改变,如干眼、睑板腺功能障碍、角膜上皮损伤等。本文对2型糖尿病患者的眼表病变及其发病机制的研究进展进行综述,为临床诊断和治疗提供理论依据。

Diabetes mellitus can result in many ocular complications,such as retinopathy,optic neuropathy,neovascular glaucoma and metabolic cataract,and plays an important role in causing blindness.In addition to diabetic retinopathy,the incidence of diabetic ocular surface diseases is also increased.Diabetes can lead to changes in the ocular surface including the lacrimal glands,tarsal glands,conjunctiva,tear film and cornea,such as dry eye,meibomian gland dysfunction,and corneal epithelial damage.This article reviews the research progress of ocular surface lesions and the pathogenesis in type 2 diabetes mellitus,hoping to provide theoretical basis for its clinical diagnosis and treatment.