二甲双胍联合炔雌醇环丙孕酮治疗多囊卵巢综合征的效果

Effects of Metformin Combined with Ethinyl Estradiol Cyproterone on Polycystic Ovary Syndrome

目的: 探讨二甲双胍联合炔雌醇环丙孕酮治疗多囊卵巢综合征(PCOS)的效果。 方法: 选取我院2017年1月至2018年1月PCOS病例90例,以随机数表采用简单随机分组方法分为对照组(口服炔雌醇环丙孕酮)和观察组(口服炔雌醇环丙孕酮+二甲双胍),每组45例,进行相应治疗,记录两组患者临床资料,检测治疗前后患者血清半乳糖凝集素-3(Galectin-3)水平、性激素、血脂、空腹血糖和胰岛素水平等指标。 结果: 治疗前,观察组和对照组各指标比较均无显著性差异(P>0.05);治疗后,观察组体质量指数(BMI)、腰臀比(WHR)、Galectin-3、黄体生成素(LH)、睾酮(T)、雌二醇(E 2),甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血清葡萄糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)治疗前后差值及排卵率、妊娠率均显著高于对照组,流产率均显著低于对照组,差异均有统计学意义(P<0.05);观察组卵泡刺激素(FSH)、总胆固醇(TC)与对照组比较,差值均无显著性差异(P>0.05)。 结论: 二甲双胍联合炔雌醇环丙孕酮对PCOS有较好的治疗效果,可有效调节性激素水平、缓解胰岛素抵抗。

Objective: To investigate the effect of Metformin combined with Ethinyl Estradiol Cyproterone in the treatment of polycystic ovary syndrome (PCOS). Methods: 90 PCOS cases in our hospital from January 2017 to January 2018 were randomly divided into control group (oral Ethinylestradiol Cycloprogesterone) and observation group (oral Ethinylestradiol Cycloprogesterone + Metformin) by the random number table with simple randomization method, 45 cases in each group, corresponding treatment was given. The clinical data of the two groups were recorded .Serum galactose lectin - 3 (Galectin - 3) level, sex hormones, blood lipid, fasting blood sugar, insulin levels and other indicators of the patients were measured before and after treatment. Results: Before treatment, there was no significant difference between the observation group and the control group (P>0.05). After treatment, the difference before and after treatmentthe of body mass index (BMI), waist-to-hip ratio (WHR), Galectin-3 level, luteinizing hormone (LH), testosterone (T), estradiol (E 2), triglyceride (TG), high-density lipoprotein (HDL),low-density lipoprotein (LDL) and fasting serum glucose (FPG), fasting insulin (FINS), homeostasis model assessment-insulin resistance index (HOMA-IR) and ovulation rate and pregnancy rate were significantly higher than those of the control group, abortion rate was significantly lower than those of the control group, and the difference were statistically significant (P<0.05). There were no significant differences in the difference between follicle stimulating hormone (FSH) and total cholesterol (TC) in the observation group and the control group (P>0.05). Conclusion: Metformin combined with Ethinyl Estradiol Cyproterone has a good therapeutic effect on PCOS,which can effectively regulate sex hormone levels and alleviate insulin resistance.