内镜下套扎序贯硬化剂注射治疗食管静脉曲张破裂出血的效果观察

Curative effect of endoscopic sequential variceal ligation plus sclerotherapy on esophageal varices bleeding

目的:探究内镜下套扎序贯硬化剂注射治疗食管静脉曲张破裂出血的效果观察。方法:选取某院就诊的食管静脉曲张破裂出血患者114例,随机分成观察组和对照组,每组各57例。对照组行内镜下套扎术(EVL)治疗,观察组行内镜下套扎序贯硬化剂注射(EVLS)治疗。比较2组患者的临床疗效、急诊止血率、近期再出血率、远期再出血率、治疗前后2组患者血清胃泌素(GAS)、胰高血糖素(GLC)及并发症发生率。结果:治疗后,观察组患者临床疗效高于对照组,远期再出血率低于对照组,差异有统计学意义(P<0.05);2组患者GAS、GLC水平均较治疗前下降,且观察组低于对照组(P<0.05);2组患者并发症发生率比较差异无统计学意义(P>0.05)。结论:内镜下套扎序贯硬化剂注射治疗较单一内镜套扎术临床疗效更好,可有效改善患者胃肠激素水平,预防远期出血,且不会增加并发症发生率。

Objective:To explore curative effect of endoscopic sequential variceal ligation plus sclerotherapy(EVLS) on esophageal varices bleeding.Methods:A total of 114 patients with esophageal varices bleeding were enrolled and randomly divided into an observation group and a control group,57 cases in each.The control group underwent endoscopic variceal ligation(EVL), while the observation group was treated with EVLS. The clinical curative effect, emergency hemostasis rate, short-term and long-term re-bleeding rate, levels of serum gastrin(GAS) and glucagon(GLC) before and after treatment, and occurrence of complications during treatment were compared between the two groups.Results:After treatment,clinical curative effect and long-term re-bleeding rate of the observation group were higher and lower respectively than those of the control group(P<0.05);levels of GAS and GLC in both groups decreased, more significantly in the observation group than in the control group(P<0.05). There was no significant difference in terms of incidence of complications between the two groups(P>0.05).Conclusion:The clinical curative effect of EVLS is better than that of EVL.The application of EVLS can effectively improve levels of gastrointestinal hormones and prevent long-term bleeding, without increasing incidence of complications.