法莫替丁联合硫糖铝对急性胃炎疗效及安全性Meta分析

Meta Analysis of the Efficacy and Safety of Famotidine Combined with Sucralfate in the Treatment of Acute Gastritis

目的:采用Meta分析评价法莫替丁联合硫糖铝对急性胃炎的临床疗效及安全性.方法:网络检索文献数据库,外文数据库有WebofScience、Pubmed、NCBI、CochraneLibrary(2018年第5期).中文数据库有中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普科技(VIP)、万方数据库(Wanfang Data).时间为建库至2019年3月.手动查询纸质文献、专业期刊杂志、学术会议论文集、最新学术期刊及未公开发表的研究,收集有关法莫替丁联合硫糖铝治疗急性胃炎疗效及安全性随机对照实验,并依据Cochrane handbook推荐的文献评价方法评价文献质量,使用Revman5.3.5处理数据.结果:法莫替丁联合硫糖铝对急性胃炎疗效优于单用法莫替丁[RR=1.17;95%C(I 1.09~1.25),P<0.00001],所纳入文献基本观察不到不良反应,安全性较高.结论:目前有限的证据表明,法莫替丁联合硫糖铝可以显著提高急性胃炎治疗效果,安全性较好.

Objective:meta analysis was used to evaluate the efficacy and safety of famotidine combined with sucralfate in the treatment of acute gastritis.Methods:literature databases were searched on the Internet.For⁃eign databases included web of science,PubMed,NCBI,Cochrane Library(issue 5,2018).Chinese databas⁃es include CNKI,CBM,VIP and Wanfang Data.The time was from construction to March 2019.The paper documents,professional journals,academic conference papers,latest academic journals and unpublished studies were manually inquired,and the randomized controlled trials on the efficacy and safety of famotidine combined with sucralfate in the treatment of acute gastritis were collected.The quality of the literature was evaluated according to the literature evaluation method recommended by Cochrane Handbook,and the data were processed by Revman 5.3.5.Results:meta analysis showed that famotidine combined with sucralfate was superior to famotidine alone in the treatment of acute gastritis[RR=1.17;95%CI(1.09-1.25),P<0.00001],no adverse reactions were observed and the safety was high.Conclusion:at present,the limited ev⁃idence shows that famotidine combined with sucralfate can significantly improve the therapeutic effect of acute gastritis,and the safety is better.