器官移植供者来源性感染防治的研究进展

Research progress on prevention and treatment of donor-derived infection in organ transplantation

器官移植是治疗终末期器官衰竭的首选有效治疗方法,供者来源性感染(DDI)与移植术后受者感染发生率和病死率显著相关。供者筛选技术的改进以及早期的防治可以提高移植的安全性。本文总结了DDI细菌感染、真菌感染、病毒感染以及寄生虫感染的病原体特征,并就其防治的研究进展进行了简述,以期为减少DDI提供参考。

Organ transplantation is the primary effective treatment for end-stage organ failure.Donor-derived infection(DDI)is significantly associated with the incidence of infection and mortality of the recipients after organ transplantation.Improvement of donor screening technology and early prevention and treatment can improve the safety of transplantation.In this article,the pathogenic characteristics of DDI bacterial infection,fungal infection,viral infection and parasitic infection were summarized,and the research progress upon the prevention and treatment were briefly introduced,aiming to provide reference for reducing DDI.