摘要
白细胞介素(IL)是由白细胞产生又在白细胞间发挥调节作用的细胞因子,包括IL-1、IL-18、IL-33和IL-37。它们分别通过激活细胞凋亡的信号通路,加剧缺血性心肌损伤;激活体内巨噬细胞和淋巴细胞,诱导产生γ干扰素,影响患者心肌收缩;或通过下调促炎因子IL-17和肿瘤坏死因子-α水平,上调IL-10表达发挥抗心力衰竭作用。目前,抗细胞因子治疗心力衰竭处于基础研究领域,尚未正式应用于临床。未来,对其进行深入研究将为慢性心力衰竭的治疗提供新方向。
Interleukin(IL)is a cytokine produced by white blood cells,and regulating white blood cells,including IL-1,IL-18,IL-33 and IL-37.They aggravate ischemic myocardial injury by activating apoptotic signaling pathways;they activate macrophages and lymphocytes in vivo,induce the production of interferon-γand affect myocardial contraction;down-regulate the levels of pro-inflammatory factor IL-17 and tumor necrosis factor-α,up-regulate the expression of IL-10 to play an anti-heart failure role.At present,anti-cytokine therapy for heart failure is in the basic research field,and has not been formally applied in clinical practice.In the future,in-depth study will provide a new direction for the treatment of chronic heart failure.
作者
杨荣荣
王志禄
YANG Rongrong;WANG Zhilu(Department of Cardiovascular Medicine,the First School of Clinical Medicine/the First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《医学综述》
2020年第1期45-49,共5页
Medical Recapitulate
