慢性不可预计温和刺激抑郁模型的研究进展

Research Progress in Chronic Unpredictable Mild Stress Depression Model

抑郁症主要表现为持久的心境失落,是一种严重的心理障碍疾病,发病因素较多,应激性事件是触发抑郁症产生的重要因素。慢性不可预计温和刺激抑郁模型与人类抑郁症的发生具有较好的相关性,其主要机制与下丘脑-垂体-肾上腺皮质轴被激活,脑内海马、前额叶皮质、多巴胺边缘系统损害有关。慢性不可预计温和刺激抑郁模型可很好地模拟人类日常生活中遭遇的不良事件,与临床抑郁症的发病机制相似,可用于各类抗抑郁药物的筛选及作用机制研究,是目前应用最广泛的模型之一。

Depression is mainly characterized by persistent mood loss,which is a serious mental disorder with a plenty of pathogenic factors.Stress event is an important factor in triggering depression.The pathogenesis of the unpredictable mild depression stimulation model has good correlation with human depression,which is related to the activation of hypothalamic-pituitary-adrenal axis,the damage of hippocampus,prefrontal cortex and dopamine limbic system in brain.The animal model can well simulate the difficulties in daily life,which can be used for the compound screening and mechanism research of various antidepressants,and is one of the most widely used models.