乌司他丁对脓毒症休克导致多器官功能衰竭的保护作用

Protective Effect of Ulinastatin on Various Organs in Septic Shock

脓毒症休克主要与机体受到外界刺激后产生和释放的大量炎症因子有关,其本质是组织细胞缺血缺氧,临床治疗以抗炎和增加血管活性为主,但病死率仍较高。乌司他丁是从健康人体液中分离出的一种蛋白酶抑制剂,可抑制多种水解酶的活性,控制过度炎症反应,改善机体微循环状态,缓解器官由于缺血再灌注所导致的损伤,减少细胞凋亡,对脓毒症休克患者肺脏、心脏、肝脏、肾脏、脑、肠道及胰腺等器官均有一定保护作用,已广泛用于脓毒症休克的治疗。

Septic shock is mainly related to a large number of inflammatory factors produced and released by the body after being stimulated by the outside world.The essence of septic shock is ischemia and hypoxia of tissue cells.The main clinical treatment is anti-inflammatory and increase of vascular activity,but the mortality is still high.Ulinastatin is a protease inhibitor isolated from healthy human body fluid,which can inhibit the activity of many hydrolases,control excessive inflammatory reaction,improve the microcirculation state of the body,alleviate the injury of organs caused by ischemia reperfusion,and reduce cell apoptosis.Ulinastatin has a certain protective effect on the lung,heart,liver,kidney,brain,intestine,pancreas and other organs of the patients,and has been widely used in the treatment of septic shock.