经颅多普勒超声联合血清超敏C反应蛋白水平对缺血性脑卒中的诊断价值

Diagnostic value of transcranial doppler ultrasound combined with serum high sensitive C-reactive protein level in ischemic stroke

目的探讨经颅多普勒超声(TCD)联合血清超敏C反应蛋白(hs-CRP)水平对缺血性脑卒中(CIS)的诊断价值。方法选取本院收治的CIS患者125例作为研究组,选取同期健康体检者132例作为对照组,血清hs-CRP水平单独及联合诊断CIS的价值。结果研究组患者PSV、EDV、MV均显著低于对照组(P<0.05),PI值及血清hs-CRP水平均明显高于对照组(P<0.05)。轻度、中度、重度脑梗死患者PSV、EDV、MV、PI值及血清hs-CRP水平比较差异均有统计学意义(P<0.05);腔隙性、小面积、大面积脑梗死患者PSV、EDV、MV、PI值及血清hs-CRP水平比较差异均有统计学意义(P<0.05)。TCD检查参数PSV、EDV、MV、PI值联合血清hs-CRP水平诊断CIS的效能高于TCD检查参数、血清hs-CRP水平单独诊断的效能。结论TCD检查参数PSV、EDV、MV、PI值联合血清hs-CRP水平可提高对CIS的诊断效能。

Objective To investigate the diagnostic value of transcranial Doppler ultrasound(TCD)combined with serum high-sensitivity C-reactive protein(hs-CRP)in ischemic stroke(CIS).Methods One hundred and twenty-five cases of CIS patients administered to in our hospital were selected as the study group,and 132 cases of healthy physical examination during the same period were selected as the control group.TCD was performed in all subjects,the peak systolic flow velocity(PSV),end diastolic flow velocity(EDV),mean blood flow velocity(MV)and pulsation index(PI)were recorded,the serum hs-CRP level was measured by rate transmission immunoturbidimetry.The ROC of subjects was drawn,the diagnostic values of TCD parameters and serum hs-CRP levels alone and combination in CIS were evaluated.Results The PSV,EDV and MV in the study group were significantly lower than those in the control group(P<0.05),and the PI value and serum hs-CRP level were significantly higher than those in the control group(P<0.05).There were significant differences in PSV,EDV,MV,PI and hs-CRP levels among patients with mild,moderate and severe cerebral infarction(P<0.05).There were significant differences in PSV,EDV,MV,PI and hs CRP levels in patients with lacunar,small area and large area cerebral infarction(P<0.05).The AUC of TCD parameters PSV,EDV,MV and PI combined with serum hs-CRP levels in diagnosing CIS was higher than that of TCD parameters and serum hs-CRP levels alone.Conclusions TCD parameters including PSV,EDV,MV and PI combined with serum hs-CRP level can improve the diagnostic efficiency of CIS.