早期给予小剂量多巴胺联合呋塞米治疗心力衰竭临床和安全性分析

Clinical and Safety Analysis of Early Administration of Low-dose Dopamine Combined with Furosemide in the Treatment of Heart Failure

目的探讨早期给予小剂量多巴胺联合呋塞米治疗心力衰竭临床疗效和安全性。方法方便选取2017年8月—2018年6月该院诊治心力衰竭患者80例进行研究,用随机分组表分为干预组(小剂量多巴胺联合呋塞米治疗,40例)和常规组(呋塞米治疗,40例),比较两组患者治疗前后心功能及疗效。结果治疗前,干预组和常规组BNP、LVDD和LVEF水平,差异无统计学意义(P>0.05);治疗7 d后,与治疗前比较,干预组和常规组BNP和LVDD水平均有显著下降,LVEF水平显著升高,差异有统计学意义(P<0.05);相对常规组,干预组患者BNP、LVDD水平显著下降,LVEF水平升高[(556.4±45.6)pg/mL vs(716.8±46.9)pg/mL,(33.5±5.2)mm vs(40.9±5.9)mm,(50.8±7.6)%vs(46.1±6.0)%,差异有统计学意义(t=4.457、4.569、3.069;P=0.000、0.000、0.002)]。干预组患者治疗总有效率显著高于常规组[97.50%vs 80.00%(χ^2=4.507,P=0.033)]。结论在心力衰竭患者中,早期给予小剂量多巴胺、呋塞米联合治疗,可对患者心脏功能有显著改善,具有显著临床疗效。

Objective To investigate the clinical efficacy and safety of early administration of low-dose dopamine combined with furosemide in the treatment of heart failure.Methods Select 80 case of heart failure patients in the hospital during August,2017 to Jue,2018 as studying object,and was convenienty selected and divided into the intervention group(40 patients treated with low-dose dopamine and furosemide)and the conventional group(40 patients treated with furosemide).Cardiac function and efficacy were compared between the two groups before and after treatment.Results Before treatment,there was no statistically significant difference in BNP,LVDD and LVEF levels between the intervention group and the routine group(P>0.05).After 7 days of treatment,compared with before treatment,the BNP and LVDD levels in the intervention group and the conventional group were significantly decreased,and the LVEF level was significantly increased.High the difference was statistically significant(P<0.05);compared with the conventional group,the BNP and LVDD levels of the intervention group decreased significantly,and the LVEF level increased[(556.4±45.6)pg/mL vs(716.8±46.9)pg/mL,(33.5±5.2)mm vs(40.9±5.9)mm,(50.8±7.6)%vs(46.1±6.0)%(t=4.457,4.569,3.069,P=0.000,0.000,0.002)].The total effective rate of treatment in the intervention group was significantly higher than that in the conventional group[97.50%vs 80.00%(χ^2=4.507,P=0.033)].Conclusion In patients with heart failure,early treatment with small doses of dopamine and furosemide can significantly improve the patient's cardiac function and have a significant clinical effect.