无内皮移植的后弹力层剥离手术促进中央角膜内皮再生的研究进展

Research progress of descemetorhexis without endothelial keratoplasty promoting corneal endothelial regeneration

角膜内皮功能损害传统上被认为是不可逆的,角膜内皮移植几乎是目前唯一的治疗方式。然而,近来出现的仅剥离Descemet膜而无内皮移植的手术(DWEK)可使Fuchs角膜内皮营养不良患者中央角膜内皮细胞再生,而局部Rho相关激酶抑制剂可以促进其疗效。

·Endothelial dysfunction is traditionally considered irreversible,and endothelial keratoplasty(EK) is almost the only treatment available.Recently,however,a surgery called descemetorhexis without endothelial keratoplasty(DWEK) can regenerate the central corneal endothelial cells in patients with Fuchs endothelial corneal dystrophy(FECD),and local Rho-associated kinase inhibitor can enhance its efficacy.