息肉样脉络膜视网膜病变患者血清细胞因子检测及危险因素分析

Detection of serum cytokines and analysis of risk factors in patients with polypoid choroidal vasculopathy

目的:探讨息肉样脉络膜视网膜病变(PCV)患者血清细胞因子水平变化,并对其危险因素进行分析。方法:选取2018-12/2019-05我院50例PCV患者作为观察组,50例预行白内障手术的年龄相关性白内障患者作为对照组,比较两组患者血清中炎性因子与新生血管因子水平,并对其一般临床资料进行单因素及多因素Logistic分析。结果:观察组患者血清中白细胞介素-8(IL-8)、单核细胞趋化蛋白-1(MCP-1)、血管内皮生长因子(VEGF)及色素上皮衍生因子(PEDF)水平均显著高于对照组(P<0.01);两组患者吸烟史与高血压有差异(P <0.05);Logistic分析结果表明,血清中IL-8、MCP-1、VEGF、PEDF水平升高、吸烟史与高血压是PCV的独立危险因素。结论:PCV患者血清中IL-8、MCP-1、VEGF和PEDF水平均异常升高,其发生与吸烟史和高血压关系密切。

·AIM:To investigate the changes of serum cytokines in patients with polypoid chorioretinopathy and analyze its risk factors.·METHODS:Select 50 cases of PCV patients in our hospital from December 2018 to May 2019 served as observation group,50 cases of senile cataract patients who want to undergo cataract surgery served as control group.The levels of inflammatory factors and angiogenic factors were compared between the two groups,and the general clinical data were analyzed by single factor and logistic regression.·RESULTS:The levels of IL-8,MCP-1,VEGF and PEDF in the observation group were significantly higher than those in the control group(P<0.01).The results of ANOVA showed that there was significant difference between smoking history and hypertension between the two groups(P<0.05);Logistic regression analysis showed that the increased levels of IL-8,MCP-1,VEGF,PEDF,smoking history and hypertension were independent risk factors for PCV.·CONCLUSION:The serum levels of IL-8,MCP-1,VEGF and PEDF in PCV patients were all increased abnormally,which was closely related to smoking history and hypertension.