6种常用5-HT3受体拮抗剂药学特点及药物经济学评价

Pharmaceutical Characteristics and Pharmacoeconomics Comparison of 6 Commonly Used 5-HT3 Receptor Antagonists

目的:通过对比分析,评价6种5-HT3受体拮抗剂药学特点差异及预防顺铂化疗所致急性呕吐成本-效果。方法:收集6种5-HT 3类止吐药药学资料,从用法用量、特殊人群、不良反应等方面进行比较、总结;运用循证医学的方法收集6种治疗呕吐药物的临床资料,应用药物经济学成本-效果分析方法评价分析。结果:6种药物在药学特点方面差异不明显,格拉司琼预防顺铂所致急性呕吐有效率为91.28%,增长的成本-效果比亦最低。结论:格拉司琼在预防顺铂所致急性呕吐中有较好的收益。

Objective:Through comparative analysis,to evaluate 6 kinds of 5-HT 3 receptors antagonists on the difference of pharmaceutical characteristics and the cost-effectiveness in preventing acute vomiting caused by cisplatin chemotherapy.Methods:Pharmaceutical data of 6 kinds of anti-vomiting drugs were collected,and the usage and dosage,special population use and adverse reactions were compared and summarized.The clinical data of 6 kinds of anti-vomiting drugs were collected by evidence-based medicine method,and evaluated and analyzed by pharmacoeconomic cost-effectiveness analysis.Results:There was no significant difference in pharmaceutical characteristics of the six drugs.The effective rate of Granisetron was 91.28%in preventing vomiting induced by Cisplatin,and the cost-effectiveness ratio was the lowest.Conclusion:Granisetron is effective in preventing vomiting induced by cisplatin.