PCG与卵巢癌关系的研究

Study on the Relationship Between PCG and Ovarian Cancer

卵巢癌是女性生殖系统最常见的恶性肿瘤之一,具有早期难以诊断、晚期生存率低及预后差的特点。因此,在临床上迫切需要寻找一种新的靶向标志物,以优化当前卵巢癌的诊疗。除癌基因及抑癌基因突变引起肿瘤外,表观遗传变化也参与肿瘤的发生发展。PCG蛋白作为表观遗传相关基因的沉默因子,与肿瘤的发生发展密切相关。本文就PCG的组成及其与肿瘤的关系、PCG关键亚基的结构及其与卵巢癌的关系作一综述,以期为临床治疗提供参考依据。

Ovarian cancer is one of the most common malignant tumors in the female reproductive system.It is difficult to diagnose early,has low survival rates,and has a poor prognosis.Therefore,it is urgently needed to find a new targeting marker in clinic to optimize the current diagnosis and treatment of ovarian cancer.In addition to tumors caused by mutations of oncogenes and tumor suppressor genes,epigenetic changes are also involved in the development of tumors.As a silencing factor of epigenetic related genes,PCG protein is closely related to tumorigenesis and development.This article reviews the composition of PCG and its relationship with tumors,the structure of key PCG subunits,and its relationship with ovarian cancer,with a view to providing reference for clinical treatment.