影响胃癌患者术后吻合口瘘的多因素分析

Multivariate analysis of postoperative anastomotic leakage in patients with gastric carcinoma

目的探讨可能影响胃癌患者术后吻合口瘘发生的因素。方法对2016年9月至2018年6月北京大学肿瘤医院行择期胃癌根治手术的499例患者病历资料回顾性研究。采用Logistic回归分析术后吻合口瘘的相关因素。结果499例胃癌患者中,发生术后吻合口瘘23例(4.6%)。术后吻合口瘘相关因素有切除范围大(OR=2.633,P=0.045)、术中发生低血压(OR=4.617,P=0.007)、术后疼痛(OR=2.838,P=0.022)和饮酒史(OR=2.809,P=0.022)。结论切除范围大、术中发生低血压、术后疼痛和饮酒史是术后吻合口瘘的危险因素。

Objective To explore the influencing factors of postoperative anastomotic leakage in patients with gastric carcinoma.Methods The clinical data of 499 patients that underwent elective radical gastrectomy at Peking University Cancer Hospital from September 2016 to June 2018 were retrospectively reviewed.Logistic regression was used to analyze the related factors of postoperative anastomotic leakage.Results Among 499 patients with gastric carcinoma,a total of 23 cases(4.6%)had postoperative anastomotic leakage.And the factors related to the postoperative anastomotic leakage included large resection range(OR=2.633,P=0.045),intraoperative hypotension(OR=4.617,P=0.007),postoperative pain(OR=2.838,P=0.022)and drinking history(OR=2.809,P=0.022).Conclusion Large resection range,intraoperative hypotension,postoperative pain and drinking history were risk factors for postoperative anastomotic leakage.