KylinRay-IMRT与Pinnacle^3胸部肿瘤计划剂量学比较分析

Dosimetric comparison between KylinRay-IMRT and Pinnacle^3 TPS in thoracic tumor plans

目的:分析两套不同放射治疗计划系统(TPS)之间的计划优化质量,验证并评价调强放射治疗计划KylinRay-IMRT 5.0的逆向计划优化功能。方法:从例题库选取15例胸部例题并导入至调强放射治疗计划系统KylinRay-IMRT,在KylinRay-IMRT计划系统中进行优化计算并确认优化结果,从TPS提取剂量学指标值并记录,数据比较进行t检验。结果:两组TPS计划的靶区均匀性指数(HI)、适形度指数(CI)、剂量分布满足临床要求,KylinRay-IMRT计划在靶区HI上略优于对照TPS组(t=4.480;P=0.001)。KylinRay-IMRT计划肺的V10、V20、V30、平均剂量(t=2.594、6.672、3.471、6.225;P<0.05)略优于对照TPS组,心脏的V30、V40、平均剂量(t=6.078、6.466、8.712;P<0.05)明显优于对照TPS组。两组靶区CI(t=-1.548;P=0.144)、肺的V5(t=1.339;P=0.202)、脊髓最大剂量(t=1.465;P=0.165)无统计学意义。结论:对于胸部例题而言,由于TPS自身因素和人为因素导致两者计算结果存在差异,KylinRay-IMRT的计划质量在临床可接受的程度范围内,其逆向计划优化功能满足了临床应用的安全性和准确性要求。

Objective To verify and evaluate the capability of inverse planning optimization of KylinRay-IMRT 5.0 for intensity-modulated radiotherapy(IMRT)by analyzing the quality of planning optimizations with two different treatment planning systems(TPS).Methods Fifteen thoracic tumor plans selected from case database were imported into KylinRay-IMRT for optimization calculations,and the optimization results were confirmed with those of Pinnacle3TPS.The dosimetric index values selected from TPS were obtained and compared with t test.Results The homogeneity index,conformity index and dose distribution of two kinds of TPS plans satisfied the clinical requirements.The homogeneity index of target areas in KylinRay-IMRT plan was slightly better than that in control TPS plan(t=4.480;P=0.001).The V10,V20,V30 and mean dose of lungs in KylinRay-IMRT plan were slightly better than those in control TPS plan(t=2.594,6.672,3.471,6.225;P<0.05),and the V30,V40 and mean dose of heart in KylinRay-IMRT plan were superior to those in control TPS plan(t=6.078,6.466,8.712;P<0.05).No statistical significance was found in the conformity index of target areas(t=-1.548;P=0.144),lung-V5(t=1.339;P=0.202)and the maximum dose to spinal cord(t=1.465;P=0.165).Conclusion For cases of thoracic tumors,there are differences in the optimization outcomes of the two TPS due to TPS itself and human factors.The quality of KylinRay-IMRT plan is proved to be within the acceptable range,and its capability of inverse planning optimization satisfies the requirements of clinical safety and validity.