摘要
本文采用以对甲苯磺酸为催化剂,经Pechmann缩合反应,合成7-羟基-4-甲基香豆素(A1)。再以A1为原料,经酰化反应,经TLC监测合成5种香豆素酯类衍生物(B1-B5),其结构经核磁共振谱(~1H NMR)确证。
7-hydroxy-4-methyl-2 H-chromen-2-one(A1) was synthesized by Pechmann condensation reaction with p-toluenesulfonic acid as catalyst. Using A1 as raw materials, five kinds of coumarin ester derivatives(B1-B5) were prepared by acylation reaction and TLC monitoring. Their structures were confirmed by ~1 H NMR.
作者
宋楠
张艺菲
危成辉
张旦
白丽丽
Song Nan;Zhang Yifei;Wei Chenghui;Zhang Dan;Bai Lili(School of Pharmacy,Hainan Medical University,Haikou 571199,China)
出处
《广东化工》
CAS
2020年第1期33-33,14,共2页
Guangdong Chemical Industry
基金
国家级大学生创新创业项目(201711810022)
海南医学院大学生创新创业项目(HYCX2016023)
关键词
7-取代
香豆素
化学合成
7-substituted
coumarin
chemical systhesis
