输尿管结石患者体外冲击波碎石术后口服盐酸坦索罗辛缓释胶囊对预后的影响分析

Effects of Oral Tamsulosin Hydrochloride Sustained-release Capsules on Prognosis in Patients with Ureteral Calculi after Extracorporeal Shock Wave Lithotripsy

目的:探讨输尿管结石患者体外冲击波碎石术后口服盐酸坦索罗辛缓释胶囊对预后的影响。方法:选取200例输尿管结石患者为研究对象,随机将其分为对照组(体外冲击波碎石术治疗)、观察组(在对照组的基础上口服盐酸坦索罗辛缓释胶囊)各100例。比较2组的结石排出时间、碎石成功率、结石总排净率;统计治疗结束3、6个月的复发率。结果:观察组经过治疗后,结石排出时间少于对照组(P<0.05),观察组、对照组的碎石成功率比较,差异无统计学意义(P>0.05),观察组的结石总排净率高于对照组(P<0.05);观察组、对照组治疗后3个月复查时结石复发率比较,差异无统计学意义(P>0.05),观察组治疗后6个月复查时结石复发率低于对照组(P<0.05)。结论:输尿管结石患者体外冲击波碎石术后口服盐酸坦索罗辛缓释胶囊有利于缩短结石排出时间,结石总排净率较高,结石复发率更低。

Objective: To explore the effects of oral tamsulosin hydrochloride sustained-release capsules on prognosis of patients with ureteral calculi after extracorporeal shock wave lithotripsy. Methods: 200 patients with ureteral calculi were selected for the study and were randomly assigned to control group(extracorporeal shock wave lithotripsy)and observation group(oral tamsulosin hydrochloride sustained-release capsules on the basis of control group)according to the random number table method, with 100 cases in each group. The stone discharge time, success rate of lithotripsy and total discharge rate of stones in the two groups were compared. The recurrence rate was recorded at 3 months and 6 months after the end of treatment. Results: After treatment, the stone discharge time in observation group was less than that in control group(P<0.05), and there was no difference in success rate of lithotripsy between observation group and control group(P>0.05). The total discharge rate of stones in observation group was higher than that in control group(P<0.05). There was no difference in recurrence rate of stones at review at 3 months after treatment between observation group and control group(P>0.05), and the recurrence rate of stones in observation group at review at 6 months after treatment was lower than that in control group(P<0.05). Conclusion: Oral tamsulosin hydrochloride sustained-release capsules in patients with ureteral calculi after extracorporeal shock wave lithotripsy is beneficial to shorten the stone discharge time, and it has high total stone discharge rate and low stone recurrence rate.