高危型人乳头瘤样病毒DNA检测在宫颈癌早期筛查中的应用

Application of High-risk Human Papillomatoid Virus DNA Detection in Early Cervical Cancer Screening

目的:探讨分析高危型人乳头瘤样病毒DNA检测在宫颈癌早期筛查中的应用。方法:选取在我院进行宫颈癌早期筛查的患者共480例,随机分为两组,给予A组患者重复细胞学检查,在3个月后复查液基细胞学,实施阴道镜下多点活检干预,结果呈阴性患者半年之后接受液基细胞学检查;B组患者实施高危型人乳头瘤样病毒DNA检测,检测结果呈阳性患者实施阴道镜下多点活检,结果呈阴性患者实施定期随访。结果:实施重复细胞学检查方法检出率为30.42%,高危型人乳头瘤样病毒DNA检测方法的检出率为40%,两组对比差异显著,P<0.05;在慢性炎症,CINⅠ、CINⅡ、CINⅢ和宫颈癌当中,高危型人乳头瘤样病毒负荷量呈现上升趋势,在进行检验之后,CINⅠ、CINⅡ、慢性炎症之间存在显著差异,P<0.05,且高危型人乳头瘤样病毒负荷量与宫颈病变程度存在较大关联性。结论:给予宫颈癌早期筛查患者高危型人乳头瘤样病毒DNA检测方法,可以尽早发现病变症状,相比于重复细胞学检查方式来说,该种检测方法能够达到快速,准确检查效果,并且高危型人乳头瘤样病毒负荷量与宫颈病变程度之间呈正相关关系。

Objective: To investigate the application of high-risk human papilloma virus DNA detection in early cervical cancer screening. Methods: 480 patients with early cervical cancer screening in our hospital were selected and randomly divided into two groups. Patients in group A were given repeated cytological examinations, and liquid-based cytology was reviewed 3 months later. Multi-point colposcopy biopsy was performed. Intervention, patients with negative results received liquid-based cytology six months later;patients in group B underwent high-risk human papillomavirus DNA testing;patients with positive results underwent multi-point biopsy under colposcopy;patients with negative results were followed up regularly. Results: The detection rate of the repeated cytological examination method was 30.42%, and the detection rate of the high-risk human papillomavirus DNA detection method was 40%, There was a significant difference between the two groups(P<0.05). In chronic inflammation, CINⅠ, CINⅡ Among CINⅢ, CINⅢ and cervical cancer, the load of high-risk human papillomavirus showed an upward trend. After testing, there were significant differences between CINⅠ, CINⅡ, and chronic inflammation, P<0.05, and high-risk human papillomavirus load There is a large correlation between the amount and the degree of cervical lesions. Conclusion: To give the high-risk human papillomatoid virus DNA detection method to patients with early cervical cancer screening, we can find the symptoms as early as possible. Compared with the repeated cytological examination method, this kind of detection method can achieve rapid and accurate examination results. There was a positive correlation between high risk human papillomatoid virus load and cervical lesions.