多受体途径联用药物治疗膀胱过度活动症的临床效果研究

Clinical Effect of Combination of Multiple Receptor Pathways in the Treatment of Overactive Bladder

目的:探讨多受体途径联用药物治疗膀胱过度活动症的临床效果。方法:选取我院收治的膀胱过度活动症(OAB)患者140例进行研究,患者均行多受体途径联用药物治疗,即予以患者丙米嗪、托特罗定、多沙唑嗪等联合用药治疗,分析其治疗效果。结果:本组患者治疗总有效率为84.3%;治疗前后比较,患者膀胱过度活动症症状评分(OABSS)、尿动力学各指标情况差异均存在统计学意义(P<0.05);患者不良反应均可耐受,无一例因不良反应而退出研究。结论:多受体途径联用药物疗法在改善膀胱过度活动症患者病情及症状方面效果显著,可推广应用。

Objective: To investigate the clinical effect of combination of multiple receptor pathways in the treatment of overactive bladder. Methods: 140 patients with overactive bladder(OAB) admitted to our hospital were selected for the study. All patients were treated with multi-receptor pathway combined drug therapy, i. e. imipramine, tolterodine and doxazosin, and their therapeutic effects were analyzed. Result: The total effective rate of this group was 84.3%. There were significant differences in OABSS and urodynamic indexes before and after treatment(P<0.05). The adverse reactions of patients were tolerable, and none of them dropped out of the study because of adverse reactions. Conclusion: Multi-receptor pathway combined drug therapy is effective in improving the condition and symptoms of patients with overactive bladder, and can be popularized.