独活化学成分及药理活性研究进展

Research Advances on Chemical Constituents and Pharmacological Effects of Angelica pubescens

独活始载于《神农本草经》,为我国传统中药。主要含有香豆素、挥发油等类化学成分,具有抗氧化、抗炎、抗肿瘤、抗老年痴呆等药理活性。近年来,国内外研究报道,已从独活中分离得到94个化合物,其中香豆素类化合物69个,其他类化合物25个。本文主要对独活的植物资源分布、化学成分和药理活性研究进展进行了综述,旨在为促进独活植物资源的开发应用提供参考。

Angelica pubescens is Traditional Chinese medicine,which was first collected in the scriptures of Shennong Herbal Medicine.It mainly contains coumarins,volatile oils and other chemical compositions.It has pharmacological activities,such as antioxidative,anti-inflammatory,antitumor,anti-senile dementia activities and so on.According to research reports of domestic and foreign in the last 35 years,it has been separated 94 compounds including 69 coumarins and 25 other compounds from Angelica pubescens.In this review,we summarized plant resource distribution,chemical composition and pharmacological activities of A.pubescens.It provides a reference for the development and application of A.pubescens.