盐酸柯诺拉赞的安全药理学研究

Safety pharmacology study of carenoprazan hydrochloride

为了探讨盐酸柯诺拉赞对SD大鼠中枢神经系统和Beagle犬心血管及呼吸系统的用药安全性,对大鼠单次灌胃给予超纯水,盐酸柯诺拉赞20、60、200 mg/kg和盐酸氯丙嗪20 mg/kg,进行功能观察组合试验,观察一般体征、行为方面、神经方面、自主体征等指标。犬单次经十二指肠给予超纯水,盐酸柯诺拉赞1、3、10 mg/kg,观察麻醉犬的心率、血压及呼吸等指标。结果表明:除200 mg/kg剂量外,其余剂量的盐酸柯诺拉赞对动物的神经系统、心血管系统及呼吸系统均无影响。在上述剂量下的盐酸柯诺拉赞药物安全性较好,具有良好临床应用前景。

To evaluate the safety of carenoprazan hydrochloride on nervous system of SD rats and cardiovascular system,respiratory system of Beagle dogs,SD rats were orally administrated with ultra-pure water,20,60,200 mg/kg doses of carenoprazan hydrochloride and 20 mg/kg dose of chlorpromazine hydrochloride,respectively.The functional observation battery was performed on tested rats to observe indicators about general physical signs,behavioral aspects,neurological aspects and autonomous signs.Ultra-pure water and 1,3,10 mg/kg doses of carenoprazan hydrochloride were given to the anesthetized dogs.The heart rate,mean arterial pressure and other related indicators of the anesthetized dogs were observed.Results suggested that 20 and 60 mg/kg doses of carenoprazan hydrochloride had no significant effect on the nervous system of SD rats,1,3 and 10 mg/kg doses of carenoprazan hydrochloride had no significant effect on cardiovascular system and respiratory system of Beagle dogs.Under the conditions,carenoprazan hydrochloride had a good security except for 200 mg/kg in rats.