黄芪汤加减治疗气虚痰瘀型慢性阻塞性肺疾病的疗效

Therapeutic effects of Huangqi decoction for treatment of patients with chronic obstructive pulmonary disease of Qi deficiency and phlegm stasis type

目的研究黄芪汤加减治疗气虚痰瘀型慢性阻塞性肺疾病(COPD)的疗效。方法选取乌鲁木齐市中医医院2017年3月至2018年5月收治的稳定期气虚痰瘀型COPD患者89例作为研究对象,根据治疗方式不同将其分为观察组46例和对照组43例,对照组采用常规西医治疗,观察组在此基础上加用黄芪汤加减进行治疗,观察2组患者临床治疗效果,治疗前后肺功能变化情况。采用χ2检验比较临床治疗效果的差异,采用独立样本t检验与配对样本t检验比较肺功能各指标与圣乔治呼吸问卷(SGRQ)指标的组间差异和治疗前后的差异。结果观察组临床治疗总有效率高于对照组(97.83%vs 62.79%),差异具有统计学意义(χ2=17.654,P<0.001)。观察组治疗后肺功能用力肺活量、1秒钟用力呼气容积和第1秒用力呼气容积肺活量比值均高于对照组[(57.71±9.79)%vs(50.53±8.62)%;(62.18±9.80)%vs(56.52±8.71)%;(67.77±13.01)%vs(61.77±10.05)%],差异均具有统计学意义(t=3.662、2.872、2.423,P<0.001、=0.005、=0.017)。治疗后观察组生活质量评分低于对照组[(27.55±8.60)分vs(35.12±9.55)分],差异具有统计学意义(t=5.775,P<0.001)。结论黄芪汤加减治疗气虚痰瘀型COPD可显著改善患者肺功能并提升其生活质量。

Objective To evaluate the therapeutic effects of Huangqi decoction on patients with chronic obstructive pulmonary disease(COPD)of Qi deficiency and phlegm stasis type as well as its impact on pulmonary function.Methods Eighty-nine patients with COPD of Qi deficiency and phlegm stasis type admitted to Urumqi Hospital of traditional Chinese Medicine from March 2017 to May 2018 were included.According to treatment method used,they were divided into an observation group(46 cases)and a control group(43 cases).Both groups were treated with conventional Western medicine.The observation group was additionally treated with Huangqi decoction.The therapeutic effects of the two groups were compared by theχ^2 test.The additionally differences of pulmonary function index and St George's respiratory questionnaire index between groups and before and after treatment were compared by the independent sample t-test and matched sample t-test.Results The total effective rate in the observation group was 97.83%,which was significantly higher than that of the control group(62.79%)(χ^2=17.654,P<0.001).The forced vital capacity,forced expiratory volume in one second,and forced expiratory volume vital capacity ratio in the first second after treatment in the observation group were higher than those of the control group([57.71±9.79]%vs[50.53±8.62]%,t=3.662,P<0.001;[62.18±9.80]%vs[56.52±8.71]%,t=2.872,P=0.005;[67.77±13.01]%vs[61.77±10.05]%,t=2.423,P=0.017).After treatment,the quality of life in the observation group was significantly poorer than that of the control group([27.55±8.60]points vs[35.12±9.55]points,t=5.775,P<0.001).Conclusion Huangqi decoction is effective in the treatment of patients with COPD of Qi deficiency and phlegm stasis type,and it can improve the lung function and quality of life of the patients.