Beneficial effects of AAV1-Rheb(S16H) administration in the adult hippocampus

Neurotrophic factors against neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD):A clear understanding of the etiology of neurodegenerative diseases,such as AD and PD remains elusive.Although there is still no therapy to prevent or block neurodegeneration,in vivo and in vitro experimental results have shown that the direct administration of neurotrophic factors,such as brain-derived neurotrophic factor(BDNF)and ciliary neurotrophic factor(CNTF),and the induction of these neurotrophic factors via specific gene delivery may protect neurons against neurotoxicity in neurodegenerative disease models(Kim et al.,2012;Jeong et al.,2013,2015).