不同方法治疗卵巢癌的效果及对患者生存质量的影响比较

Effect comparison of different methods in the treatment of ovarian cancer and their impact on patients′ quality of life

目的比较不同方法治疗卵巢癌的效果及对患者生存质量的影响。方法选取2015年1月~2017年10月我院收治的58例卵巢癌患者作为研究对象,根据随机数字表法分为实验组与对照组,每组各29例。实验组患者术前接受紫杉醇+卡铂(TC)化疗+肿瘤细胞减灭术+术后腹腔内TC灌注+术后常规化疗,而对照组患者仅行细胞减灭术+术后常规化疗。比较两组患者的手术情况、治疗效果、生存质量评分、并发症发生情况、复发率及死亡率。结果实验组患者的手术时间、住院时间均短于对照组,差异有统计学意义(P<0.05);实验组患者的失血量[(425.29±142.73)ml]、腹水量[(670.35±163.87)ml]均少于对照组[(801.62±125.26)、(893.40±164.38)ml],差异有统计学意义(P<0.05);实验组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者治疗前的生存质量评分比较,差异无统计学意义(P>0.05);实验组患者治疗后的情绪功能、总健康状况评分均高于治疗前和对照组,而疼痛、疲倦、便秘、气促评分均低于治疗前和对照组,差异有统计学意义(P<0.05);对照组患者的疼痛、疲倦评分低于治疗前,差异有统计学意义(P<0.05);两组患者的并发症发生率比较,差异无统计学意义(P>0.05);实验组患者的复发率及死亡率均低于对照组,差异有统计学意义(P<0.05)。结论对于卵巢癌患者,术前TC化疗+肿瘤细胞减灭术+术后腹腔TC热灌注+术后常规化疗的方法相比仅行肿瘤细胞减灭术+术后常规化疗具有更好的疗效,可在临床上推广应用。

Objective To compare the effect of different methods in the treatment of ovarian cancer and their impact on patients′quality of life.Methods A total of 58 patients with ovarian cancer from January 2015 to Octorber 2017 were selected as the subjects,and divided as the experimental group and control group by random number table method,with 29 cases in each group.The experimental group was treated with preopearative Paclitaxel+Carboplatin(TC)chemotherapy+cytoreductive surgery+peritoneal TC thermofusion+postoperative conventional chemotherapy,and the control group recerived cytoreductive surgery+postoperative routine chemotherapy.The operation condition,treatment effect,quality of life score,complications,recurrence rate and mortality of the two groups were compared.Results The operation time and hospitalization time of the experimental group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The amount of blood loss([425.29±142.73]ml)and ascites([670.35±163.87]ml)in the experimental group were less than those in the control group([801.62±125.26],[893.40±164.38]ml),and the differences were statistically significant(P<0.05).The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the quality of life scores between the two groups before treatment(P>0.05).The scores of emotional function and total health status in the experimental group were higher than those before treatment and the control group,while the scores of pain,fatigue,constipation and shortness of breath in the experimental group were lower than those before treatment and the control group,and the differences were statistically significant(P<0.05).The scores of pain and fatigue in the control group were lower than before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).The recurrence rate and mortality rate of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion For patients with ovarian cancer,preopearative TC chemotherapy+cytoreductive surgery+peritoneal TC thermofusion+postoperative conventional chemotherapy has better curative effect than tumor cytoreductive surgery+postoperative conventional chemotherapy,which can be widely used in clinic.