注射用甲泼尼龙琥珀酸钠与复方磺胺甲恶唑片联用对中重度缺氧艾滋病患者伴肺孢子菌肺炎的临床疗效观察

Clinical efficacy of injection of methylprednisolone sodium succinate and compound sulfamethoxazole tablets in patients with moderate to severe hypoxic AIDS complicated with pneumocystis pneumonia

目的:探讨甲强龙注射用甲泼尼龙琥珀酸钠与复方磺胺甲噁唑复方磺胺甲恶唑片联用对中重度缺氧艾滋病患者伴肺孢子菌肺炎的临床疗效。方法:在医院2017年12月至2018年11月期间诊治的中重度缺氧艾滋病伴发肺孢子菌肺炎患者中选取94例作研究对象,并进行药物治疗:将单纯采取复方磺胺甲噁唑复方磺胺甲恶唑片治疗者设为对照组(n=47),将采取甲强龙注射用甲泼尼龙琥珀酸钠与复方磺胺甲噁唑复方磺胺甲恶唑片联用方案者设为研究组(n=47),就2组两组患者整体疗效以及肺部病变、治疗前后血气分析指标变化进行统计学分析。结果:①研究组患者整体治疗有效率是95.74%,高于对照组的80.85%(X^2=5.045,P=0.025);②治疗后,研究组患者的血气分析指标PaO2水平高于对照组(t=7.761,P=0.000)、SpO2水平低于对照组(t=9.843,P=0.000)。结论:甲强龙注射用甲泼尼龙琥珀酸钠与复方磺胺甲噁唑复方磺胺甲恶唑片联用对中重度缺氧艾滋病患者伴肺孢子菌肺炎的临床疗效显著,可借鉴。

Objective To investigate the clinical efficacy of injection of methylprednisolone sodium succinate and compound sulfamethoxazole tablets in patients with moderate to severe hypoxic AIDS with pneumocystic pneumonia.Methods 94 patients with moderate to severe hypoxic AIDS and pneumocystis pneumonia were treated in the hospital from December 2017 to November 2018.The drug was treated with compound sulfamethoxazole tablets.The control group was treated with compound sulfamethoxazole tablets alone.The study group was treated with methylprednisolone sodium succinate for injection and compound sulfamethoxazole tablets.The changes of blood gas analysis indexes before and after treatment were statistically analyzed.Results 1 The overall treatment efficiency of the study group was 95.74%,which was higher than that of the control group 80.85%(X^2=5.045,P=0.025).After treatment,the blood gas analysis index PaO2 level of the study group was higher than that of the control group(t=7.761,P=0.000),the level of SpO2 was lower than that of the control group(t=9.843,P=0.000).Conclusion The combination of methylprednisolone sodium succinate for injection and compound sulfamethoxazole tablets has a significant clinical effect on patients with moderate to severe hypoxic AIDS with pneumocystis pneumonia.