墨玉县40岁以上维吾尔族农村居民高三酰甘油腹围表型和慢性肾脏病的关系

The Relationship Between Hypertriglyceridemic-Waist Phenotype and Chronic Kidney Disease Among Uygurs Aged 40 Years and Elder in Moyu Country

目的:分析40岁以上维吾尔族农村居民高三酰甘油腹围(HW)表型与慢性肾脏病(CKD)的关系。方法:在“新疆墨玉县农村维吾尔族成人慢性肾脏病流行病学调查”资料库中,获取40岁以上居民资料635份,根据三酰甘油及腹围分为3组,第1组:三酰甘油增高且腹围增高组(HW),第2组:三酰甘油增高或腹围增高组。第3组:三酰甘油且腹围正常组,用SPSS 15.0分析3组人群表型分布特征及与CKD的关系。结果:该人群3组表型所占比例依次为:19.37%(95%CI:16.30~22.44),36.85%(95%CI:33.10~40.60),43.77%(95%CI:39.92~47.64),女性HW表型比例显著高于男性(P<0.01),40~60岁组和大于60岁组的HW表型分布差异无统计学意义。三组表型的CKD患病率为:15.45%(95%CI:9.06~21.80),7.69%(95%CI:4.28~11.11),7.91%(95%CI:4.74~11.09),第1组HW表型的CKD患病率显著高于第2组(χ2=5.219,P<0.05)。logistic回归分析校正性别,年龄,高血压,糖尿病,吸烟,饮酒等混杂因素后HW表型与CKD患病显著相关(OR=2.63,95%CI:1.14~6.07,P<0.05),年龄≥60岁(OR=2.33,95%CI:1.29~4.19,P<0.01),高血压(OR=2.79,95%CI:1.43~5.45,P<0.01)是维吾尔族40岁以上人群HW表型者患CKD的危险因素。结论:维吾尔族农村40岁以上人群HW表型与CKD患病率相关。

Objective:To examine the correlation between the HW phenotype and risk of chronic kidney disease among Uygurs aged 40 years and elder in Xinjiang.Methods:The data were collected form the survey of chronic kidney diseases among Uygurs in Xinjiang,The participants(635)aged 40 years and elder were divided into three groups.group1:hypertriglyceridemic-waist phenoltype,group2:hypertriglyceridemic or elevated waist circumference,group 3:normal triglyceridemic and elevated waist circumference.The prevalence of the three groups and the relationship between HW phenotype and chronic kidney diseases were analyzed using SPSS 15.0.Results:The prevalence of three phenotypes were:19.37%(95%CI:16.30~22.44),36.85%(95%CI:33.10~40.60)and 43.77%(95%CI:39.92~47.64)respectively,and women have a much higher prevalence of hypertriglyceridemic-waist phenotype than men,no correlation was found between age and prevalence(P<0.05).The prevalence of CKD among three groups was 15.45%(95%CI:9.06~21.80),7.69%(95%CI:4.28~11.11)and 7.91%(95%CI:4.74~11.09)respectively,The incidence of CKD was higher in group 1 than group 2 and 3(χ2=5.219,P<0.05).When adjusted for potential confounders such as sex,age,hypertension,diabetics,smoker,alcohol use and so on,Independent risk factors associated with CKD among Uygurs aged 40 years were:hypertriglyceridemic-waist phenotype(OR=2.63,95%CI:1.14~6.07,P<0.05),60 years and older(OR=2.33,95%CI:1.29~4.19,P<0.01),hypertension(OR=2.79,95%CI:1.43~5.45,P<0.01).Conclusion:The hypertriglyceridemic-waist phenotype was associated with CKD among Uygurs aged 40 years and elder in country.