肺癌中IMP3的表达及其临床病理意义

Expression of IMP3 in lung cancer and its clinicopathological significance

目的探讨胰岛素样生长因子ⅡmRNA结合蛋白3(insulin-like growth factor II mRNA-binding protein 3,IMP3)在肺癌中的表达及其临床病理意义。方法采用免疫组化和荧光定量PCR法检测178例肺癌组织中IMP3蛋白及mRNA的表达,分析其表达与肺癌临床病理特征及预后的关系。结果与癌旁组织相比,肺癌组织中IMP3蛋白及mRNA表达水平均显著上调(P<0.01)。IMP3蛋白表达水平与患者性别、病理类型、病理学分期、血清CEA水平有关(P<0.05)。Kaplan-Meier单因素分析显示IMP3表达、淋巴结转移、病理学分期与患者的疾病无进展生存期(progression-free survival,PFS)有关,淋巴结转移、吸烟与总生存期(overall survival,OS)有关(P<0.05)。Cox多因素分析显示IMP3表达、淋巴结转移、肿瘤直径是PFS的独立影响因素;病理学分期是OS的独立影响因素(P<0.05)。结论IMP3表达与肺癌的发生、发展密切相关,是肺癌患者疾病进展的独立预测因子。

Purpose To investigate the expression and clinicopathological significance of insulin-like growth factor II mRNA-binding protein 3(IMP3)in lung cancer.Methods Immunohistochemistry and fluorescent quantitative PCR were used to detect the expression of IMP3 protein and mRNA in 178 patients of lung cancer.The relationships between IMP3 expression and clinicopathological characteristics,as well as clinical prognosis were analyzed.Results Compared with adjacent tissues,the expression levels of IMP3 protein and mRNA in lung cancer tissues were significantly up-regulated(P<0.01).The expression of IMP3 was related to gender,pathological type,pathological stage and serum CEA level of the patients(P<0.05).Kaplan-Meier univariate analysis suggested that IMP3 expression,lymph node metastasis,pathological stage were associated with progression-free survival(PFS),while lymph node metastasis and smoke were associated with overall survival(OS)(P<0.05).Cox multivariate analysis suggested that IMP3 expression,lymph node metastasis,and tumor size were independent factors influencing PFS,while pathological stage was an independent risk factor associated with OS(P<0.05).Conclusion The expression of IMP3 is closely related to the occurrence and development of lung cancer.It is an independent predictor of disease progression in lung cancer patients.