糖尿病肾脏疾病的发病机制研究进展

Research progress in pathogenesis of diabetic kidney disease

糖尿病肾脏疾病(diabetic kidney disease,DKD)是影响全世界的公共卫生问题,是糖尿病患者发病和死亡的主要原因,也是终末期肾病的主要原因。因其缺乏有效的治疗手段,对其机制的研究一直是临床研究的热点。肾脏血流动力学变化、氧化应激、炎症等都与DKD的发病机制有关,而相关研究指出代谢记忆和表观遗传学对DKD的进展中起着重要的作用,在这篇综述中,将结合目前的最新研究概述DKD发病机制的进展。

Diabetic kidney disease(DKD)is a worldwide public health problem,which is the major cause for morbidity and mortality of patients with diabetes,and the main cause for end-stage kidney diseases.Because of the lack of effective treatment,the research on its mechanism has been the focus of clinical studies.The changes of renal hemodynamics,oxidative stress,inflammation and so on are all related to the pathogenesis of DKD,and the related studies point out that metabolic memory and epigenetics play an important role in the progression of DKD.In this review,we will summarize the progress of the pathogenesis of diabetic kidney disease in combination with the latest studies.