阿尔兹海默病的发病机制及药物治疗研究进展

Research progress on pathogenesis and treatment of Alzheimer’s disease

阿尔兹海默病(Alzheimer’s disease,AD)是老年痴呆中最常见的类型,属于慢性的神经退行性疾病。AD是与年龄密切相关的疾病,伴随社会人口老龄化的到来,AD的发病率明显增加,防治AD已成为全球性的重大研究课题。近年来,针对AD的发病机制以及相关药物治疗取得了新进展,通过归纳AD的发病机制以及药物治疗的研究进展,以期为AD相关研究提供参考。

Alzheimer’s disease(AD), which belongs to the central nervous system(CNS) neurodegenerative disorder, is the most common form of dementia in late adult people. The incidence of AD is highly correlated to aging, and AD is the leading cause of morbidity and disability for the aged people. As the ageing population community comes, increased attention should be paid to the prevention and treatment of AD. Over the last several decades, advances in the field of pathogenesis and pharmacological therapeutics have updated and inspired the researchers for the investigation of novel drug therapy. In this review, we will discuss the different aspects of etiology of AD and its management, and provide some insight for AD research.