利培酮联合丙戊酸钠治疗精神分裂症攻击行为的效果

Effect of risperidone combined with valproate in the treatment of aggressive behavior in schizophrenia

目的研究利培酮联合丙戊酸钠治疗精神分裂症攻击行为的效果。方法选取2018年3月至2019年1月我院收治的60例精神分裂症患者(MOAS总分>4分)作为研究对象。采用随机数字表法将患者分为对照组(30例)与试验组(30例)。对照组患者采用利培酮治疗,试验组患者采用利培酮联合丙戊酸钠治疗。比较两组的临床疗效和不良反应发生情况。比较两组患者治疗前及治疗1、5、12周的MOAS及BPRS评分。结果试验组的治疗总有效率为93.33%,高于对照组的73.33%,差异具有统计学意义(P<0.05)。试验组的不良反应总发生率为3.33%,低于对照组的20.00%(P<0.05)。治疗前,两组患者的MOAS及BPRS评分比较,差异无统计学意义(P>0.05);治疗1、5、12周,试验组患者的MOAS及BPRS评分明显低于治疗前及对照组,差异具有统计学意义(P<0.05)。结论利培酮联合丙戊酸钠治疗精神分裂症攻击行为效果显著,可改善患者的症状,安全性高,值得临床应用推广。

Objective To study the effect of risperidone combined with valproate in the treatment of aggressive behavior in schizophrenia. Methods Sixty schizophrenics(total score of MOAS>4 points) admitted in our hospital from March 2018 to January 2019 were selected as the study objects. The patients were divided into control group(30 cases) and experimental group(30 cases) by random number table method. The control group was treated with risperidone, and the experimental group was treated with risperidone and valproate. The clinical efficacy and adverse reactions of the two groups were compared. The scores of MOAS and BPRS of the two groups were compared before treatment and at 1, 5, 12 weeks after treatment. Results The total effective rate of treatment in the experimental group was 93.33%, which was higher than 73.33% in the control group, and the difference was statistically significant(P <0.05). The total incidence of adverse reactions in the experimental group was 3.33%, which was lower than 20.00% in the control group(P <0.05). Before treatment, there were no significant differences in the scores of MOAS and BPRS between the two groups(P>0.05);at 1, 5,12 weeks after treatment, the scores of MOAS and BPRS in the experimental group were significantly lower than those before treatment and in the control group, and the differences were statistically significant(P <0.05). Conclusion Risperidone combined with valproate in the treatment of aggressive behavior in schizophrenia has significant effect, it can improve the symptoms of patients with high safety, which is worthy of clinical application and promotion.