芪苈强心胶囊治疗心力衰竭的临床效果及对患者心功能、脑钠素及炎性因子水平的影响

Clinical effect of Qili Qiangxin capsule in the treatment of heart failure and its influences on cardiac function, brain natriuretic peptide and inflammatory factors levels of patients

目的探究芪苈强心胶囊治疗心力衰竭的临床效果及对患者心功能、脑钠素[血浆N末端B型钠尿肽原(NT-proBNP)]及炎性因子水平的影响。方法将我院2017年1月至2018年6月收治的78例慢性心力衰竭患者随机分为对照组(39例,西药治疗)与研究组(39例,西药治疗+芪苈强心胶囊)。比较两组患者的临床疗效、治疗前、后的心功能、NT-proBNP及炎性因子水平。结果研究组的临床治疗总有效率为92.31%,明显高于对照组的71.79%(P<0.05)。治疗后,两组的LVEF、LVEDD、LVESD、E/A均较治疗前改善,且研究组明显优于对照组(P<0.05)。治疗后,两组的NT-porBNP、TNF-α、IL-6、CRP水平均较治疗前下降,且研究组明显低于对照组(P<0.05)。结论芪苈强心胶囊治疗心力衰竭的临床效果显著,可改善患者的心功能,降低NT-proBNP及炎性因子水平。

Objective To explore the clinical effect of Qili Qiangxin capsule in the treatment of heart failure and its influences on cardiac function, N-terminal pro-B-type natriuretic peptide(NT-proBNP) and inflammatory factors levels of patients. Methods A total of 78 patients with chronic heart failure admitted in our hospital from January 2017 to June 2018 were randomly divided into control group(39 cases, western medicine treatment) and study group(39 cases, western medicine treatment +Qili Qiangxin capsule). The clinical effects, cardiac function, NT-proBNP and inflammatory factors levels before and after treatment of the two groups were compared. Results The total effective rate of clinical treatment in the study group was 92.31%, which was significantly higher than 71.79% in the control group(P<0.05). After treatment, the levels of LVEF, LVEDD, LVESD and E/A in the two groups improved, and those in the study group were significantly better than the control group(P <0.05). After treatment, the levels of NT-proBNP, TNF-α, IL-6 and CRP in the two groups were lower than those before treatment, and those in the study group were significantly lower than the control group(P <0.05). Conclusion Qili Qiangxin capsule in the treatment of heart failure has a significant clinical effect, which can improve the cardiac function of patients, and reduce the levels of NT-proBNP and inflammatory factors.