期刊文献+

环丙沙星联合多索茶碱治疗慢性阻塞性肺疾病的临床效果 被引量:2

Clinical effect of ciprofloxacin combined with doxofylline in the treatment of chronic obstructive pulmonary disease
下载PDF
导出
摘要 目的探讨环丙沙星联合多索茶碱治疗慢性阻塞性肺疾病的临床效果。方法选择2015年11月至2018年11月我院收治的180例慢阻肺患者为研究对象,采用随机数字法将其分为参照组和联合治疗组,每组90例。参照组给予β2受体激动剂(沙丁胺醇)、抗胆碱药物(异丙托溴铵)等常规治疗,联合治疗组在此基础上采用环丙沙星联合多索茶碱治疗。比较两组患者的治疗效果。结果治疗后,两组患者的IFN-γ、TNF-ɑ、IL-8水平均降低,且联合治疗组低于参照组(P<0.05)。治疗后,两组患者的PaO2、SaO2均升高,且联合治疗组高于参照组(P<0.05);治疗后,两组患者的PaCO2均降低,且联合治疗组低于参照组(P<0.05)。治疗后,两组患者的MVV、FVC、FEV1均升高,且联合治疗组高于参照组(P<0.05)。联合治疗组治疗总有效率明显高于参照组(P<0.05)。结论环丙沙星联合多索茶碱治疗慢阻肺患者效果显著,值得推广应用。 Objective To explore the clinical effect of ciprofloxacin combined with doxofylline in the treatment of chronic obstructive pulmonary disease. Methods A total of 180 patients with chronic obstructive pulmonary disease admitted in our hospital from November 2015 to November 2018 were selected as the study objects, and the patients were divided into reference group and combined treatment group by random number method, with 90 cases in each group. The reference group was treated with β2 receptor agonist(salbutamol) and anticholinergic drug(ipratropium bromide), and the combined treatment group was treated with ciprofloxacin and doxofylline on this basis. The therapeutic effects of the two groups were compared. Results After treatment, the levels of IFN-γ, TNF-α, IL-8 in the two groups decreased, and those in the combined treatment group were lower than the reference group(P<0.05). After treatment, PaO2 and SaO2 in the two groups increased, and those in the combined treatment group were higher than the reference group(P <0.05);after treatment, PaCO2 in both groups decreased, and that in the combined treatment group was lower than the reference group(P<0.05). After treatment, MVV, FVC and FEV1 of the two groups increased, and those of the combined treatment group were higher than the reference group(P<0.05). The total effective rate of treatment of the combined treatment group was significantly higher than that of the reference group(P <0.05). Conclusion Ciprofloxacin combined with doxofylline is effective in the treatment of chronic obstructive pulmonary disease, which is worth popularizing and applying.
作者 李海军 刘瑜 LI Hai-jun;LIU Yu(Xianyang Central Hospital,Xianyang 712000,China)
机构地区 咸阳市中心医院
出处 《临床医学研究与实践》 2020年第2期50-52,共3页 Clinical Research and Practice
关键词 环丙沙星 多索茶碱 慢性阻塞性肺疾病 肺功能 ciprofloxacin doxofylline chronic obstructive pulmonary disease lung function
  • 引文网络
  • 相关文献

参考文献10

二级参考文献60

共引文献123

同被引文献27

引证文献2

;
使用帮助 返回顶部