硫唑嘌呤联合泼尼松龙治疗自身免疫性肝病的效果

Efficacy of Azathioprine combined with Prednisolone in the treatment of autoimmune liver disease

目的探讨硫唑嘌呤联合泼尼松龙治疗自身免疫性肝病的效果。方法选取2018年3~12月沈阳医学院附属中心医院收治的106例自身免疫性肝病(AILD)患者作为研究对象,按照随机数字表法将其分为观察组(51例)和对照组(55例)。观察组患者采用泼尼松龙联合硫唑嘌呤治疗,对照组患者采用泼尼松龙单药治疗。比较两组患者的治疗效果、肝功能情况和肝脏超声弹性值。结果观察组患者的治疗总有效率[86.27%(46/51)]高于对照组[70.90%(35/55)],半乳糖基葡糖基转移酶(GGT)[(126.49±19.26)U/L]、天门冬氨酸氨基转移酶(AST)[(55.72±25.36)U/L]、谷氨酸氨基转移酶(ALT)[(65.57±29.36)U/L]、总胆红素(TBil)[(23.47±8.53)mmol/L]均低于对照组[(155.22±36.22)U/L、(70.39±26.39)U/L、(81.44±16.37)U/L、(28.51±6.73)mmol/L],肝脏超声弹性值[(7.47±2.56)kPa]低于对照组[(9.22±1.37)kPa],差异均有统计学意义(P<0.05)。结论采用泼尼松龙联合硫唑嘌呤治疗自身免疫性肝病,可以有效提高患者的疗效,改善肝功能,恢复肝脏的弹性,值得临床推广应用。

Objective To investigate the effect of Azathioprine combined with Prednisolone on autoimmune liver diseases.Methods A total of 106 patients with autoimmune liver disease(AILD)admitted to Center Hospital Affiliated to Shenyang Medical College from March to December 2018 were selected as the research objects and divided into observation group(51 cases)and control group(55 cases)according to the random number table method.Patients in the observation group were treated with Prednisolone combined with Azathioprine,while patients in the control group were treated with Prednisolone alone.The therapeutic effect,liver function and ultrasonic elasticity of liver were compared between the two groups.Results The total effective rate of patients in the observation group(86.27%[46/51])was higher than that in the control group(70.90%[35/55]),galactosylglucosyltransferase(GGT)([126.49±19.26]U/L),aspartate aminotransferase(AST)([55.72±25.36]U/L),glutamate aminotransferase(ALT)([65.57±29.36]U/L),total bilirubin(TBIL)([23.47±8.53]mmol/L),both of them were lower than those of the control group([155.22±36.22]U/L,[70.39±26.39]U/L,[81.44±16.37]U/L,[28.51±6.73]mmol/L),and the ultrasonic elasticity value of liver([7.47±2.56]kPa)was lower than that of the control group([9.22±1.37]kPa),the differences were statistically significant(P<0.05).Conclusion Prednisolone combined with Azathioprine can effectively improve the curative effect of patients with autoimmune liver diseases,improve liver function and restore liver elasticity,which is worthy of clinical application.