加味参芪地黄汤治疗气阴两虚型老年慢性功能性便秘的临床效果

Clinical effect of modified Shenqi Dihuang Decoction in the treatment of senile chronic functional constipation with type of deficiency of both Qi and Yin

目的探讨加味参芪地黄汤治疗气阴两虚型老年慢性功能性便秘的临床效果。方法选取2018年1月~2019年8月我院收治的120例气阴两虚型老年慢性功能性便秘患者作为研究对象,根据随机数字表法将患者分为中药组与西药组,每组各60例。中药组给予加味参芪地黄汤治疗,西药组给予聚乙二醇4000散治疗。于治疗前及治疗后2、4、6周监测两组患者的结肠传输试验阳性率、血清P物质(SP)含量、血管活性肠肽(VIP)含量以及临床症状积分,并比较两组患者的临床效果。结果两组患者治疗后2、4、6周的结肠传输试验阳性率低于治疗前,差异有统计学意义(P<0.05);中药组患者治疗后2、4、6周的结肠传输试验阳性率低于西药组,差异有统计学意义(P<0.05);两组患者治疗后2、4、6周的血清SP水平高于治疗前,而血清VIP水平低于治疗前,差异有统计学意义(P<0.05);中药组患者治疗后2、4、6周的血清SP水平高于西药组,而血清VIP水平低于西药组,差异有统计学意义(P<0.05);两组患者治疗后2、4、6周的临床症状总积分低于治疗前,差异有统计学意义(P<0.05);中药组患者治疗后2、4、6周的临床症状总积分低于西药组,差异有统计学意义(P<0.05);中药组患者的治疗总有效率为98.33%,高于西药组的78.33%,差异有统计学意义(P<0.05)。结论加味参芪地黄汤治疗气阴两虚型便秘患者的效果显著,能够改善患者的临床症状及相关指标,值得临床推广应用。

Objective To explore the clinical effect of modified Shenqi Dihuang Decoction in the treatment of senile chronic functional constipation with type of deficiency of both Qi and Yin.Methods A total of 120 elderly patients with chronic functional constipation with type of deficiency of both Qi and Yin treated in our hospital from January 2018 to August 2019 were selected as the research objects.According to the random number table methods,the patients were divided into the Chinese medicine group and the western medicine group,with 60 cases in each group.The Chinese medicine group was treated with modified Shenqi Dihuang Decoction,and the western medicine group was treated with Polyethylene Glycol 4000 Powder.Before treatment and 2,4,6 weeks after treatment,the positive rate of colonic transit test,the contents of substance P(SP)and vasoactive intestinal peptide(VIP),clinical symptom scores of the two groups were monitored,and the clinical effect of the two groups were compared.Results The positive rate of colonic transit test in the two groups at 2,4 and 6 weeks after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).The positive rate of colonic transit test in the Chinese medicine group at 2,4 and 6 weeks after treatment were lower than those in the western medicine group,the differences were statistically significant(P<0.05).The serum SP levels of the two groups at 2,4 and 6 weeks after treatment were higher than those before treatment,while the serum VIP levels of the two groups at 2,4 and 6 weeks after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).The serum SP levels of the Chinese medicine group at 2,4 and 6 weeks after treatment were higher than those of the western medicine group,while the serum VIP levels of the Chinese medicine group at 2,4 an weeks after treatment were lower than those of the western medicine group,the differences were statistically significant(P<0.05).The total score of clinical symptoms in the two groups at 2,4 and 6 weeks after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).The total score of clinical symptoms in the traditional Chinese medicine group at 2,4 and 6 weeks after treatment were lower than those in the western medicine group,the differences were statistically significant(P<0.05).The total effective rate of the Chinese medicine group was 98.33%,which was higher than that of the western medicine group(78.33%),the difference was statistically significant(P<0.05).Conclusion The effect of modified Shenqi Dihuang Decoction in the treatment of senile chronic functional constipation with type of deficiency of both Qi and Yin is significant,which can improve the clinical symptoms and related indicators of patients,and is worthy of clinical promotion and application.