高同型半胱氨酸血症与炎性反应疾病研究进展

Research progress of hyperhomocysteinemia and inflammatory reaction diseases

同型半胱氨酸(Hcy)是一种非必需的α-氨基酸,多年来研究发现,Hcy与多种疾病存在内在联系,不仅是公认的心脑血管疾病的独立危险因素,还影响多系统疾病的发生发展。其对多系统多器官造成影响的本质是各种介质的炎性反应,高同型半胱氨酸血症通过上调促炎因子表达,增加氧化应激,促进血管、组织形态重构,导致内皮细胞功能障碍,从而影响各种系统的功能。本文拟通过对高同型半胱氨酸血症与炎性反应疾病相关性的综述,进一步系统地认识高同型半胱氨酸血症。

Homocysteine(Hcy)is a kind of nonessentialα-amino acid.Over the years,studies have found that Hcy has an internal relationship with a variety of diseases.It is not only recognized as an independent risk factor for cardiovascular and cerebrovascular diseases,but also affects the occurrence and development of multi system diseases.The essence of its effect on multi system and multi organ is inflammatory response of various media.Hyperhomocysteinemia can increase oxidative stress,promote the reconstruction of blood vessel and tissue morphology by up regulating the expression of pro-inflammatory factors,leading to endothelial cell dysfunction,thus affecting the function of various systems.In this paper,we will review the correlation between hyperhomocysteinemia and inflammatory response diseases,and further understand the hyperhomocysteinemia.