Notch和Wnt通路对脑缺血后神经干细胞作用的研究进展

Advance in Roles of Notch and Wnt Pathways for Neural Stem Cells after Cerebral Ischemia

神经干细胞(NSCs)在脑缺血后神经功能障碍的修复过程中起着关键作用。Notch通路广泛存在于动物细胞中,是调控NSCs增殖、分化的经典信号通路。Wnt通路参与细胞的增殖、分化和凋亡等过程,在损伤后脑组织NSCs增殖过程中发挥重要作用。近年来研究发现,两条通路形成一个信号网络,共同调控NSCs增殖和分化。

Neural stem cells(NSCs)play a key role in repair of neurological dysfunction after cerebral ischemia.Notch pathway widely exists in animal cells and is a classical signaling pathway regulating the proliferation and differentiation of NSCs.Wnt pathway is involved in cell proliferation,differentiation and apoptosis,and plays an important role in proliferation of NSCs in brain tissue after injury.The recent studies found that the two pathways form a signaling network to regulate proliferation and differentiation of NSCs.