肠道菌群与慢性便秘关系的研究进展

Research progress of the relationship between intestinal microbiota and chronic constipation

慢性便秘是一种常见、负担沉重的慢性疾病,很少病人会因症状求医,且治疗后远期效果不甚理想。迄今为止便秘的病因和病理生理也不是完全清楚,但肠道菌群和膳食纤维与便秘之间有着重要关系已是共识。越来越多研究证实便秘病人肠道菌群存在不同程度的紊乱,肠道微生物的改变可能改善便秘相关症状,而益生菌治疗已成为慢性便秘治疗的重要方式。益生菌可能是通过改变肠道菌群结构、代谢产物促进肠蠕动、增加粪便水分等机制改善便秘症状的。该文就从慢性便秘病人肠道菌群差异性和益生菌在慢性便秘治疗中的作用两方面进行文献综述。

Chronic constipation(CC)is a common and load-bearing disease,few patients will seek medical treatment because of constipation symptoms,and the long-term effect after treatment is not very satisfactory.So far the etiology and pathophysiology of constipation are not entirely clear,but there is a common consensus of the relationship between intestinal flora and dietary fiber and constipation.Increasing researches proved that there were different degrees of disorder in intestinal flora of patients with CC,change of intestinal microbiota may improve the constipation-related symptoms,and probiotics therapy has become an important way to treat CC.Probiotics improve constipation symptoms by altering the structure of intestinal flora,promoting intestinal peristalsis by metabolites,and increasing fecal moisture.The paper reviews the differences of intestinal flora in patients with CC and the role of probiotics in treatment of CC.