阿瑞匹坦联合昂丹司琼治疗乳腺癌化疗引起的恶心呕吐31例疗效观察

Clinical observation of aprepitant combined with ondansetron in the prevention of nausea and vomiting induced by chemotherapy of breast cancer

目的观察阿瑞匹坦联合昂丹司琼治疗化疗药物引起的恶心呕吐的疗效。方法收集内蒙古自治区人民医院2017年2月至2018年5月行化疗的乳腺癌病人62例,采用随机数字表法分为观察组(阿瑞匹坦+昂丹司琼)及对照组(昂丹司琼组),每组各31例,比较两组药物对预防化疗所致恶心、呕吐的临床疗效。结果观察组治疗恶心呕吐有效率为87.1%,优于对照组的58.1%(P<0.05);两组发生的疲乏、便秘、头痛不良反应比较差异无统计学意义(P>0.05)。结论阿瑞匹坦联合昂丹司琼注射液能够有效预防高致吐化疗药物引起的恶心呕吐,提高病人生活质量。

Objective To observe the curative effect of aprepitant combined with ondansetron in the prevention of nausea and vomiting caused by chemotherapy drugs.Methods Take the 62 breast tumors patients,who need chemotherapy,in Inner Mongolia People’s Hospital from February 2017 to May 2018 were randomly divided into observation group(aprepitant combined with ondansetron)and control group(ondansetron)the 31 cases in each group,compared two groups of drugs for prevention of clinical curative effect of chemotherapy induced nausea and vomiting.Results Among 62 patients who achieved the assessment of clinical response,the complete response rates of nausea and vomiting by aprepitant combined with ondansetron vs. ondansetron were 87.1% vs. 58.1%;the observation group is better than control group(P<0.05);The most common ADR in both regimens were fatigue,constipation,headache.There was no statistical significance in the incidence of ADR(P>0.05).Conclusion The aprepitant combined with ondansetron regimen is effective for nausea and vomiting induced by chemotherapy,with tolerable toxcity profile,improve the quality of life of patients.