银杏叶提取物联合微创清创术治疗高血压脑出血的临床观察

Clinical Observation of Ginkgo Biloba Extract Combined with Minimally Invasive Debridement for Hypertensive Intracerebral Hemorrhage

目的探讨银杏叶提取物联合微创清创术治疗高血压脑出血(hypertensive intracerebral hemorrhage,HICH)的临床疗效。方法83例HICH患者随机分为对照组(41例)和研究组(42例)。对照组给予微创清创术治疗,研究组给予银杏叶提取物联合微创清创术治疗,两组均给予治疗30d。比较两组治疗前后的美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分、改良Barthel指数(modified barthel index,MBI)评分、中文版脑卒中专门生活质量量表(stroke specific quality of life scale,SS-QOL)评分、血清超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)水平、临床疗效及治疗过程中不良反应的发生情况。结果研究组总有效率高于对照组(χ2=4.196,P=0.041)。两组治疗后NIHSS评分均低于治疗前(P均<0.05),MBI和SS-QOL评分均高于治疗前(P均<0.05),且研究组上述评分改善程度均优于对照组(P均<0.05)。两组治疗后血清hs-CRP、TNF-α及IL-6水平较治疗前均下降(P均<0.05),且研究组上述指标均比对照组低(P均<0.01)。两组患者治疗期间均未发生严重不良反应。结论银杏叶提取物联合微创清创术治疗HICH的临床疗效显著,能够改善患者神经功能,提高生活能力和生活质量,调节血清炎症因子水平,且安全性较好。

Objective To explore the clinical efficacy of ginkgo biloba extract combined with minimally invasive debridement for hypertensive intracerebral hemorrhage(HICH).Methods A total of 83 patients with HICH were randomly divided into control group(41 cases)and research group(42 cases).The control group was given minimally invasive debridement,and the research group was treated with ginkgo biloba extract combined with minimally invasive debridement.The two groups were treated for 30 days.The scores of national institutes of health stroke scale(NIHSS),modified barthel index(MBI),stroke specific quality of life scale(SS QOL),serum high-sensitivity C-reactive PR were compared before and after treatment The levels of otein,hs CRP,TNF-α,IL-6,clinical efficacy and the occurrence of adverse reactions in the course of treatment.Results The total effective rate of the research group was significantly higher than the control group(χ2=4.196,P=0.041).After treatment,NIHSS score in the two groups was significantly lower than those before treatment(P all<0.05),MBI score and SS-QOL score was significantly higher than those before treatment(P all<0.05),and the improvement of the above scores in the research group was significantly better than the control group(P all<0.05).After treatment,the levels of serum hs-CRP,TNF-αand IL-6 of the two groups were significantly lower than those before treatment(P all<0.05),and the above indexes in the research group were lower than the control group(P all<0.05).There was no serious adverse reaction during treatment in the two groups.Conclusion Ginkgo biloba extract combined with minimally invasive debridement has a significant clinical effect in treating HICH.It can improve the nerve function,the ability and quality of life,regulate the level of serum inflammatory factors,and has good safety.