联合检测β-HCG倍增率、孕酮对甲状腺功能正常孕妇先兆流产治疗效果的预测价值

Value of combined detection of β-HCG multiplication rate and progesterone forpredication of treatment effecton threatened abortion in pregnant women with normal thyroid function

目的探讨联合检测β-HCG倍增率、孕酮对甲状腺功能正常孕妇先兆流产治疗效果的预测价值。方法回顾性分析2018年1~12月在我院诊断治疗的甲状腺功能正常的先兆流产孕妇100例患者。根据治疗结果分为妊娠成功组(74例)与妊娠失败组(26例)。比较两组入组时β-HCG、孕酮水平,治疗后β-HCG倍增率。分析联合检测β-HCG、孕酮对先兆流产治疗的预测价值。结果(1)妊娠成功组入组时β-HCG水平、孕酮水平及治疗后β-HCG倍增率均显著高于妊娠失败组,差异有统计学意义(P<0.05)。(2)β-HCG倍增率、孕酮单独检测灵敏度、阴性预测值差异无统计学意义(P>0.05);联合检测的灵敏度、特异度、阴性预测值显著高于β-HCG倍增率、孕酮单独检测,差异有统计学意义(P<0.05)。联合检测阳性预测值有所提高,高于孕酮单独检测(P<0.05),但与β-HCG倍增率比较差异无统计学意义(P>0.05)。结论联合检测β-HCG倍增率、孕酮对甲状腺功能正常孕妇先兆流产治疗效果具有较好的预测作用。

Objective To investigate the value of combined detection ofβ-HCG multiplication rate and progesterone forthe prediction of treatment effect on threatened abortion in pregnant women with normal thyroid function.Methods A retrospective analysis of 100 pregnant women with normal thyroid function who were diagnosed with threatened abortion and treated in our hospital from January to December 2018 were performed.According to the treatment results,these pregnant women were divided into the pregnancy success group(74 women)and the pregnancy failure group(26 women).Theβ-HCG and progesterone levels at enrollment and theβ-HCG multiplication rates after treatment were compared between the two groups.The value of combined detection ofβ-HCG and progesterone for the predication of treatment effect on threatened abortion were analyzed.Results(1)The levels ofβ-HCG and progesterone at enrollment and theβ-HCG multiplication rateafter treatment in the successful pregnancy group were significantly higher than those in the pregnancy failure group,with statistically significant differences(P<0.05).(2)There were no significant differences in theβ-HCG multiplication rate,sensitivity of single progesterone detection and negative predictive value(P>0.05).The sensitivity,specificity and negative predictive value of combined detection were significantly higher than those of singleβ-HCG multiplication rate or progesterone detection,with statistically significant differences(P<0.05).The positive predictive value of combined detection was higher than that of single progesterone detection(P<0.05),but there was no statistically significant difference compared with the singleβ-HCG multiplication rate(P>0.05).Conclusion Combined detection ofβ-HCG multiplication rate and progesterone has a good predictive effect on the treatment effect for threatened abortion in pregnant women with normal thyroid function.