生殖道B族链球菌定植与早产的相关性研究

Correlation between colonization of group B streptococcus in genital tract and premature delivery

目的探讨妊娠期生殖道B族链球菌(group B streptococcus,GBS)定植与早产的相关性。方法选取2017年7月~2018年10月期间于本院接受正规产前检查及住院保胎的28~36+6周有早产倾向的单胎孕妇500例,采用实时聚合酶链反应(polymerase chain reaction,PCR)技术检测,比较GBS定植阳性组与阴性组母婴妊娠结局,并分析GBS定植与早产的关系。结果与GBS定植阴性组比较,GBS定植阳性组胎膜早破(16.50%vs 29.55%)、早产(5.58%vs 13.64%)、绒毛膜羊膜炎(1.94%vs 35.23%)、产后出血(2.43%vs 9.09%)及新生儿肺炎(0.97%vs 10.23%)发生率明显增加,差异均有统计学意义(P<0.01)。Logistic回归分析结果表明,GBS定植阳性是早产的危险因素(OR=2.23,95%CI:1.34~3.41,P<0.05)。结论生殖道GBS定植可导致母婴不良结局,且GBS定植是早产的危险因素。

Objective To investigate the relationship between colonization of group B streptococcus(GBS)in genital tract during pregnancy and premature delivery.Methods A total of 500 single-fetus pregnant women with premature birth tendency for 28 to 36+6 weeks who received regular prenatal examination and were hospitalized in our Hospital for preventing miscarriage from July 2017 to October 2018 were selected.Real-time polymerase chain reaction(PCR)technique was used for detection.The maternal and fetal pregnancy outcomes between the GBS colonization positive group and the negative group were compared.And the relationship between GBS colonization and preterm birth was analyzed.Results Compared with that of the GBS colonization-negative group,the incidence of premature rupture of membranes(16.50%vs 29.55%),premature delivery(5.58%vs 13.64%),chorioamnionitis(1.94%vs 35.23%),postpartum hemorrhage(2.43%vs 9.09%)and neonatal pneumonia(0.97%vs 10.23%)in GBS colonization-positive group increased significantly,and the difference was statistically significant(P<0.01).Logistic regression analysis showed that GBS colonization position was a risk factor for preterm birth(OR=2.23,95%CI:1.34-3.41,P<0.05).Conclusion GBS colonization of the reproductive tract can lead to adverse outcomes in mothers and infants,and GBS colonization is a risk factor for preterm delivery.