产后抑郁症与甲状腺功能关系的研究进展

Advances in research on the relationship between postpartum depression and thyroid function

产后抑郁症(Postpartum depression,PPD)发病率高,是生育常见的并发症之一,对产妇、婴儿、家庭和社会均可造成不可估量的损害。多种因素可引起PPD的发生,目前多项研究表明下丘脑-垂体-甲状腺(Hypothalamus-pituitary-thyroid,HPT)轴功能紊乱参与PPD的发生,但两者间的具体联系尚未明确。本文从妊娠期甲状腺功能变化、促甲状腺激素(Thyroid stimulating hormone,TSH)、游离三碘甲状原氨酸(Free triiodothyronine,FT3)、游离甲状腺素(Free thyroxine,FT4)水平变化对PPD的影响、甲状腺自身抗体与PPD的关系以及抗PPD治疗对甲状腺功能影响等方面对PPD与甲状腺功能关系研究进展做一综述,以期为深入了解和治疗PPD带来新的启示。

The incidence of postpartum depression(PPD)is high,which is one of the common complications of birth,and can cause immeasurable damage to maternal,infant,family and society.A variety of factors can cause the occurrence of PPD.At present,many studies have shown that the hypothalamic-pituitary-thyroid(HPT)axis dysfunction is involved in the occurrence of PPD,but the specific relationship between the two is not clear.The research progress on the relationship between PPD and thyroid function was reviewed from the aspects of the changes in thyroid function,the effect thyroid stimulating hormone(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)levels on PPD,the relationship between thyroid gland autoantibodies and PPD and the effect of anti-PPD treatment on thyroid function during pregnancy,in order to provide new insights for understanding and treating PPD.